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Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody

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Synonyms ICE(rel)III, ICEREL-III, ICH-3, CASP5
Cow (Bovine), Hamster, Human, Monkey, Mouse (Murine), Rat (Rattus)
(97), (5), (5), (3), (3), (3), (2)
(94), (3)
(3), (3), (3), (3), (3), (3), (1)
Western Blotting (WB)
(90), (46), (18), (17), (9), (7), (4), (3), (3), (2), (2), (1)
Pubmed 1 reference available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide surrounding amino acids 162 of human caspase-5
Blocking Peptide Blocking peptide for this product available: ABIN412653
Isotype IgG
Specificity Detects the 47 kDa procaspase-5 and the 38 kDa and 30 kDa intermediates in Western blot analysis
Purification Affinity purified
Alternative Name Caspase-5 (CASP5 Antibody Abstract)
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-5 is also known as Ich-3 and ICErel-III and can proteolytically processed by granzyme B. Over expression of caspase-5 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.
Synonyms: CASP-5, ICH-3 protease, TY protease, ICH3
Gene ID 838
NCBI Accession NP_004338
Research Area Apoptosis/Necrosis
Application Notes Western blotting (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-caspase-5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody (ABIN222884) Western blot analysis of Caspase-5 in rat kidney tissue lysate. Caspase-5 intermediat...
Product cited in: Bian, Elner, Khanna et al.: "Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 12, pp. 8646-56, 2011 (PubMed).

Catalog No. ABIN222884
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