Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody

Details for Product No. ABIN222884
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Antigen
Synonyms ICE(rel)III, ICEREL-III, ICH-3, CASP5
Reactivity
Human, Mouse (Murine), Rat (Rattus), Rabbit, Monkey, Cow (Bovine), Hamster
(81), (14), (14), (13), (11), (11), (2), (2), (2)
Host
Rabbit
(78), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(73), (34), (13), (11), (10), (10), (9), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN222884
269.50 $
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Immunogen Synthetic peptide surrounding AA 162 of human caspase-5
Isotype IgG
Specificity Detects the 47 kDa procaspase-5 and the 38 kDa and 30 kDa intermediates in Western blot analysis
Purification Affinity purified
Alternative Name Caspase-5
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-5 is also known as Ich-3 and ICErel-III and can proteolytically processed by granzyme B. Over expression of caspase-5 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.
Gene ID 838
Research Area Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody Western blot analysis of Caspase-5 in rat kidney tissue lysate. Caspase-5 intermediate (30 kDa) and full cleaved (20 kDa) fragments were detected.
Product cited in: Bian, Elner, Khanna et al.: "Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 12, pp. 8646-56, 2011 (PubMed).

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