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Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody

Details for Product No. ABIN222884, Supplier: Log in to see
Antigen
  • ICE(rel)III
  • ICEREL-III
  • ICH-3
  • CASP5
Reactivity
Cow (Bovine), Hamster, Human, Monkey, Mouse (Murine), Rat (Rattus)
97
4
4
2
2
2
2
Host
Rabbit
95
2
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
1
Application
Western Blotting (WB)
90
43
18
17
9
7
4
3
3
2
2
Supplier
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Immunogen Synthetic peptide surrounding amino acids 162 of human caspase-5
Blocking Peptide Blocking peptide for this product available: ABIN412653
Isotype IgG
Specificity Detects the 47 kDa procaspase-5 and the 38 kDa and 30 kDa intermediates in Western blot analysis
Purification Affinity purified
Alternative Name Caspase-5 (CASP5 Antibody Abstract)
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-5 is also known as Ich-3 and ICErel-III and can proteolytically processed by granzyme B. Over expression of caspase-5 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.
Synonyms: CASP-5, ICH-3 protease, TY protease, ICH3
Gene ID 838
NCBI Accession NP_004338
Research Area Apoptosis/Necrosis
Application Notes Western blotting (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-caspase-5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) antibody (ABIN222884) Western blot analysis of Caspase-5 in rat kidney tissue lysate. Caspase-5 intermediat...
Product cited in: Bian, Elner, Khanna et al.: "Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 12, pp. 8646-56, 2011 (PubMed).