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MCL-1 antibody (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1)

Details for Product anti-MCL1 Antibody No. ABIN222889, Supplier: Login to see New
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Synonyms AW556805, Mcl-1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, TM, bcl2-L-3, mcl1/EAT, mcl-1
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Human, Monkey, Mouse (Murine), Rat (Rattus)
(297), (101), (67), (9), (8), (4), (4), (3), (2), (2), (1), (1)
(208), (78), (19), (2)
This MCL-1 antibody is un-conjugated
(11), (9), (9), (6), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(249), (120), (105), (72), (57), (38), (32), (22), (21), (8), (7), (6), (1)
Pubmed 2 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1
Blocking Peptide Blocking peptide for this product available: ABIN412827
Isotype IgG
Specificity Detects 43 kDa Mcl-1
Purification Affinity purified
Alternative Name Mcl-1 (MCL1 Antibody Abstract)
Background Mcl-1 (Myeloid cell leukemia-1) is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-β1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.
Synonyms: MCL1L, mcl1/EAT, MGC1839, MGC104264, TM, MCL1S, EAT
Gene ID 4170
UniProt Q07820
Research Area Cancer, Apoptosis/Necrosis
Pathways MAPK Signaling
Application Notes Western blot analysis (0.5-4 μg/mL), Immunoprecipitation (10-20 μg/mL), and Immunohistochemistry (10-20 μg/mL).
However, the optimal conditions should be determined individually.

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Mcl-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-MCL-1 antibody (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1) (ABIN222889) Western blot analysis of Mcl-1 in Ramos cell lysate.
Product cited in: Xu, Wells, Padilla et al.: "A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance." in: Carcinogenesis, Vol. 35, Issue 11, pp. 2457-66, 2014 (PubMed).

Wang, Chen, Zeng et al.: "Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells." in: Molecular cancer therapeutics, Vol. 7, Issue 5, pp. 1156-63, 2008 (PubMed).

Catalog No. ABIN222889
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