Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (C-Term) antibody

Details for Product No. ABIN222951
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Antigen
Synonyms
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Dric ... show more
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice, A830040C14Rik, AC-3, Apopain, CPP32, Lice, Yama, mldy, CPP32B, SCA-1, xcpp32 show less
Epitope
C-Term
(30), (21), (20), (18), (15), (12), (9), (8), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(316), (117), (93), (19), (18), (18), (6), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(283), (61), (6), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (6), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(271), (122), (101), (98), (57), (31), (30), (23), (19), (18), (10), (4), (2), (2), (2)
Pubmed 8 references available
Quantity 100 μg
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Catalog No. ABIN222951
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Immunogen Synthetic peptide corresponding to the C-terminus of caspase-3 large fragment
Isotype IgG
Specificity Detects procaspase-3 and the cleaved p20 subunit in Western blot analysis
Purification Affinity purified
Alternative Name Caspase-3
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-3 is synthesized as an inactive pro-enzyme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP and DFF).
Gene ID 836
Research Area Apoptosis/Necrosis, Autophagy
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (C-Term) antibody Western blot analysis of human caspase-3 with (Lane 1) and without (Lane 2) blocking peptide.
Product cited in: Takebe, Cheng, Fandy et al.: "IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells." in: Molecular cancer therapeutics, Vol. 5, Issue 2, pp. 457-66, 2006 (PubMed).

Atkin, Farg, Turner et al.: "Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1." in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 30152-65, 2006 (PubMed).

Pietri, Caprini, Mouillet-Richard et al.: "Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells." in: The Journal of biological chemistry, Vol. 281, Issue 38, pp. 28470-9, 2006 (PubMed).

Matsuda, Yamamoto, Takano et al.: "Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 9, pp. 806-15, 2009 (PubMed).

Turpin, Ryall, Southgate et al.: "Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice." in: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1593-605, 2009 (PubMed).

Matsuda, Teramae, Yamamoto et al.: "Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA." in: American journal of physiology. Heart and circulatory physiology, Vol. 298, Issue 1, pp. H92-101, 2009 (PubMed).

General Kiran Kumar, Prabhakara Rao, Noble et al.: "Lead-induced alteration of apoptotic proteins in different regions of adult rat brain." in: Toxicology letters, Vol. 184, Issue 1, pp. 56-60, 2008 (PubMed).

James, Le, Scholey: "INFLUENCE OF GLUCOSAMINE ON GLOMERULAR MESEANGIAL CELL TURNOVER: IMPLICATIONS FOR HYPERGLYCEMIA AND HEXOSAMINE PATHWAY FLUX." in: American journal of physiology. Endocrinology and metabolism, 2009 (PubMed).

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