Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (C-Term)

Details for Product anti-CASP6 Antibody No. ABIN222958, Supplier: Log in to see
Antigen
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
  • caspase 6, apoptosis-related cysteine peptidase
  • caspase 6
  • caspase-6
  • Caspase-6
  • caspase-6-like
  • casp6
  • CASP6
  • CpipJ_CPIJ017008
  • Casp6
  • LOC100341546
  • LOC100517293
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term, Large Subunit, active
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39
15
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6
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1
1
1
1
1
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
287
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105
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5
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Host
Rabbit
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19
Clonality
Polyclonal
Biological Activity
Active
Conjugate
This Caspase 6 antibody is un-conjugated
18
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Application
Western Blotting (WB)
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145
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66
40
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19
8
5
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Options
Supplier
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Immunogen Synthetic peptide surrounding AA mapping to the C-terminus of the large fragment of human caspase-6
Isotype IgG
Specificity The antibody detects the large subunit (18 kDa) of the active caspase-6.
The antibody does not recognize other caspases.
Purification Affinity purified
Alternative Name Caspase-6 (CASP6 Antibody Abstract)
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Synonyms: CASP6, CASP-6 , MCH2
Gene ID 839
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western blotting (0.5-4 μg/mL) and immunofluorescence. However, the optimal conditions should be determined individually. The antibody detects the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize other caspases.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-active caspase-6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Vohra, Sasaki, Miller, Chang, DiAntonio, Milbrandt: "Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13729-38, 2010 (PubMed).

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