Cathepsin L1 (CTSL1) antibody

Details for Product No. ABIN222981
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Antigen
Synonyms si:dkey-121a11.6, mep, catl, ctsl, cpl-1, MGC80629, MGC107932, CTSL, CATL, CTSL1, MEP, 1190035F06Rik, Ctsl1, fs, nkt, CATHL, CatL, Ctsl, CTSL2
Reactivity
Human
(114), (51), (42), (3), (3)
Host
Rabbit
(89), (58), (4), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(12), (11), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(118), (68), (29), (16), (10), (9), (7), (7), (6), (5), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Immunogen Synthetic peptide surrounding amino acid 223 of human Cathepsin L
Isotype IgG
Specificity Detects both the proenzyme and the mature forms of cathepsin L in human sample in Western blot analysis
Purification Affinity purified
Alternative Name Cathepsin L (CTSL1 Antibody Abstract)
Background Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid pro-peptide, to generate the active two-chain form made up of 21 and 5 kDa subunits. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. The fact that Cathepsin L is also capable of degrading extracellular matrix proteins sμggests that it may play a role in invasion and metastasis and could be a useful prognostic indicator for cancer.
Synonyms: CTSL, CATL, CTSL1, MEP, EC 3.4.22.15
Gene ID 1514
UniProt P07711
Research Area Signaling, Extracellular Matrix, Cancer, Proteases
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
Comment

Suggested positive control:
Western Blot: Jurkat cell lysate. IHC: Kidney tissue

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.1 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Cathepsin L1 (CTSL1) antibody anti-Cathepsin L1 (CTSL1) antibody
Product cited in: Song, Bailey, Dunlap et al.: "Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia ..." in: Biology of reproduction, Vol. 82, Issue 5, pp. 854-64, 2010 (PubMed).

Song, Spencer, Bazer: "Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau." in: Endocrinology, Vol. 146, Issue 11, pp. 4825-33, 2005 (PubMed).

Validation Images
Catalog No. ABIN222981
297.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
297.00 $

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