Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term) antibody

Details for Product No. ABIN223017
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Epitope
C-Term
(49), (32), (23), (12), (12), (7), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(196), (91), (76), (13), (6), (2), (1)
Host
Rabbit
(180), (29), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(171), (96), (64), (49), (40), (30), (22), (13), (8), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µg
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Catalog No. ABIN223017
269.50 $
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Immunogen Synthetic peptide mapping to the C-terminus of rat caspase-6 large fragment
Isotype IgG
Purification Affinity purified
Alternative Name Caspase-6
Background Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Gene ID 83584
Research Area Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually. Jurkat cell lysate tissue lysate can be used as a positive controls.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term) antibody Western blot analysis of Caspase-6 expression rat kidney tissue lysate. Both full length and the cleaved large fragment have been detected.
Product cited in: Vohra, Sasaki, Miller et al.: "Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13729-38, 2010 (PubMed).

General Nikolaev, McLaughlin, OLeary et al.: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, 2009 (PubMed).

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