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Details for Product No. ABIN223017

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term) antibody

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Antigen
Synonyms MCH2, Mch2, mCASP-6, xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN223017
Quantity 100 µg
Price
269.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide mapping to the C-terminus of rat caspase-6 large fragment
Isotype IgG
Purification Affinity purified
Alternative Name Caspase-6
Background Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Gene ID 83584
Research Area Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually. Jurkat cell lysate tissue lysate can be used as a positive controls.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Vohra, Sasaki, Miller et al.: "Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13729-38, 2010 (PubMed).

Nikolaev, McLaughlin, OLeary et al.: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, 2009 (PubMed).

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Antibodies"
Hosts (159), (33), (2)
Reactivities (181), (93), (82), (16), (7), (4), (2), (2), (2), (2), (2)
Applications (149), (72), (63), (40), (40), (29), (25), (20), (7), (5), (4), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (43), (28), (22), (8), (7), (6), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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