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Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody

Details for Product No. ABIN223070, Supplier: Log in to see
Antigen
  • AA408698
  • Dffrx
  • faf1
  • FAF1
  • Fam
  • hFAF1
  • HFAF1s
  • MGC53741
  • MGC80303
  • UBXD12
  • UBXN3A
  • wu:fc25h12
  • zgc:55752
Reactivity
Human, Mouse (Murine), Rat (Rattus)
80
43
42
2
2
1
1
Host
Rabbit
63
17
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
65
24
20
11
7
6
6
1
1
Supplier
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Immunogen Synthetic peptide corresponding to residues surrounding amino acid 640 of human FAF1
Blocking Peptide Blocking peptide for this product available: ABIN412729
Isotype IgG
Purification Affinity purified
Alternative Name FAF1 (FAF1 Antibody Abstract)
Background FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type, but not mutated, Fas in both yeast and mammalian cells. When transiently expressed in T cells, FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD, FADD, and RIP, FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
Synonyms: FAF1 (CT), Fas-associated protein 1, hFAF1, HFAF1s, TNFRSF6, TNFRSF6 associated factor 1 antibody, FAF1
Gene ID 11124
UniProt Q9UNN5
Research Area Apoptosis/Necrosis
Application Notes Western blotting (0.5-4 μg/mL) and in Immunoprecipitation and Immunohistochemistry.
Rat kidney cell lysate can be used as a positive control.
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-FAF1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody (ABIN223070) Western blot analysis of FAF1 in rat kidney tissue extract
Product cited in: Altomare, Menges, Pei, Zhang, Skele-Stump, Carbone, Kane, Testa: "Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3420-5, 2009 (PubMed).