Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody

Details for Product No. ABIN223070
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Antigen
Synonyms faf1, MGC53741, MGC80303, FAF1, zgc:55752, wu:fc25h12, HFAF1s, UBXD12, UBXN3A, hFAF1, AA408698, Dffrx, Fam
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(59), (38), (38), (12), (12), (12)
Host
Rabbit
(54), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(48), (25), (12), (10), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN223070
297.00 $
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Immunogen Synthetic peptide corresponding to residues surrounding AA 640 of human FAF1
Isotype IgG
Purification Affinity purified
Alternative Name FAF1
Background FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type, but not mutated, Fas in both yeast and mammalian cells. When transiently expressed in T cells, FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD, FADD, and RIP, FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
Gene ID 11124
Research Area Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
Based on researchers feedback, the antibody also works well in immunoprecipitation and immunohistochemistry.
However the optimal conditions should be determined individually. Rat kidney cell lysate can be used as a positive control.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody Western blot analysis of FAF1 in rat kidney tissue extract
Product cited in: Altomare, Menges, Pei et al.: "Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3420-5, 2009 (PubMed).

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