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Details for Product No. ABIN223070

Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody

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Antigen
Synonyms HFAF1s, UBXD12, UBXN3A, hFAF1, AA408698, Dffrx, Fam, faf1, MGC53741, MGC80303, FAF1, zgc:55752, wu:fc25h12
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN223070
Quantity 100 µg
Price
269.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide corresponding to residues surrounding AA 640 of human FAF1
Isotype IgG
Purification Affinity purified
Alternative Name FAF1
Background FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type, but not mutated, Fas in both yeast and mammalian cells. When transiently expressed in T cells, FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD, FADD, and RIP, FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
Gene ID 11124
Research Area Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
Based on researchers feedback, the antibody also works well in immunoprecipitation and immunohistochemistry.
However the optimal conditions should be determined individually. Rat kidney cell lysate can be used as a positive control.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Altomare, Menges, Pei et al.: "Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 9, pp. 3420-5, 2009 (PubMed).

Alternatives for antigen "Fas (TNFRSF6) Associated Factor 1 (FAF1)", type "Antibodies"
Hosts (44), (6)
Reactivities (50), (31), (31), (12), (12), (12)
Applications (39), (23), (10), (8), (6), (4), (4), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (3), (2), (2), (1)
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