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TANK antibody (TRAF Family Member-Associated NFKB Activator)

Details for Product anti-TANK Antibody No. ABIN223072, Supplier: Log in to see
Antigen
  • C86182
  • E430026L09Rik
  • I-TRAF
  • ITRAF
  • TRAF2
Alternatives
anti-Human TANK antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
110
35
33
3
3
2
1
1
1
1
Host
Rabbit
106
3
2
1
1
Clonality
Polyclonal
Conjugate
This TANK antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
98
36
33
17
15
12
11
8
7
3
2
1
Supplier
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Immunogen Synthetic peptide surrounding amino acid 413 of human TANK
Blocking Peptide Blocking peptide for this product available: ABIN412928
Isotype IgG
Purification Affinity purified
Alternative Name TANK (TANK Antibody Abstract)
Background Members of TRAF family associate with activated TNF-R and CD40 and have been implicated to induce nuclear translocation of NFkB. TANK can bind to all three TRAFs and synergizing with TRAF2 to activate the NFkB signal cascade.
Synonyms: TANK (NT), TRAF family member-associated NF-kappaB activator, I-TRAF
Gene ID 10010
UniProt Q92844
Research Area Immunology, Innate Immunity
Pathways p53 Signaling, TLR Signaling
Application Notes Western blotting (0.5-4 μg/mL) and in Immunoprecipitation (10-20 μg/mL), and Immunohistochemistry (10-20 μg/mL).
Mouse small intestine tissue lysate can be used as a positive control.
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-TANK polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-TANK antibody (TRAF Family Member-Associated NFKB Activator) (ABIN223072) Western blot analysis of TANK with mouse small intestine tissue lysate.
Product cited in: Tanaka, Chen: "STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway." in: Science signaling, Vol. 5, Issue 214, pp. ra20, 2012 (PubMed).

Guo, Cheng: "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 11817-26, 2007 (PubMed).