TRAF Family Member-Associated NFKB Activator (TANK) antibody

Details for Product No. ABIN223072
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Antigen
Synonyms C86182, E430026L09Rik, I-TRAF, ITRAF, TRAF2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(79), (33), (33), (1), (1), (1)
Host
Rabbit
(74), (3), (3), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
(71), (30), (18), (16), (10), (9), (9), (6), (6), (3), (3)
Pubmed 2 references available
Quantity 100 µg
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Catalog No. ABIN223072
269.50 $
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  • +1 404 474 4654
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Immunogen Synthetic peptide surrounding AA 413 of human TANK
Isotype IgG
Purification Affinity purified
Alternative Name TANK
Background Members of TRAF family associate with activated TNF-R and CD40 and have been implicated to induce nuclear translocation of NFkB. TANK can bind to all three TRAFs and synergizing with TRAF2 to activate the NFkB signal cascade.
Gene ID 10010
Research Area Immunology, Innate Immunity
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
Based on researcher's feed back the antibody also works well in immunoprecipitation (10-20 µg/mL), and immunohistochemistry (10-20 µg/mL).
However the optimal conditions should be determined individually. Mouse small intestine tissue lysate can be used as a positive control.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-TRAF Family Member-Associated NFKB Activator (TANK) antibody Western blot analysis of TANK with mouse small intestine tissue lysate.
Product cited in: Guo, Cheng: "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 11817-26, 2007 (PubMed).

Tanaka, Chen: "STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway." in: Science signaling, Vol. 5, Issue 214, pp. ra20, 2012 (PubMed).

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