Cytochrome C, Somatic (CYCS) antibody

Details for Product No. ABIN223077
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Antigen
Synonyms
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, ... show more
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, CG17903, Cyt-c2, CytC-2, Cytc-p, DC4, DMc01, Dmel\\CG17903, cyt c-p, cyt-c-p, cyt-c2, dc4, pDMc01, HCS, THC4, cytc, CYCSA, wu:fk52b01, zgc:86706, ENSMUSG00000058927 show less
Reactivity
Mouse (Murine)
(135), (76), (69), (32), (23), (15), (14), (13), (13), (8), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(119), (69), (7), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(147), (54), (42), (40), (38), (27), (20), (14), (11), (10), (6), (5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Options
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Catalog No. ABIN223077
297.00 $
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Immunogen Bovine cytochrome c
Isotype IgG
Purification Affinity purified
Alternative Name Cytochrome c
Background Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases.
Gene ID 109892891
Research Area Apoptosis/Necrosis, Metabolism, Cytochrome c
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually. Mouse small intestine lysate can be used as a positive control.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Cytochrome C, Somatic (CYCS) antibody Western blot analysis of cytochrome c with mouse small intestine tissue lysate.
Product cited in: Machiya, Shibata, Yamauchi et al.: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).

Kuhn, Chen, Voorhees et al.: "Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma." in: Blood, Vol. 110, Issue 9, pp. 3281-90, 2007 (PubMed).

Zhao, Chen, Lu et al.: "TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 11, pp. 4133-41, 2008 (PubMed).

Lan, Gorke, Rau et al.: "Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4926-35, 2008 (PubMed).

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