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Cytochrome C antibody (Cytochrome C, Somatic)

Details for Product anti-CYCS Antibody No. ABIN223077, Supplier: Log in to see
Antigen
  • bln
  • bs30f07.y1
  • CG13263
  • CG17903
  • CYC
  • cyc
  • CYCS
  • cycs
  • CYCSA
  • cyct
  • cyt-c-d
  • cyt-c-p
  • Cyt-c1
  • cyt-c2
  • Cyt-c2
  • cyt.c
  • Cyt C
  • Cyt c
  • cyt c
  • Cytc
  • cytc
  • CytC-1
  • CytC-2
  • Cytc-d
  • cyt c-d
  • Cytc-p
  • cyt c-p
  • CytC1
  • cytochrome c
  • DC3
  • dc3
  • dc4
  • DC4
  • DMc01
  • Dmel\\CG13263
  • Dmel\\CG17903
  • ENSMUSG00000058927
  • hcs
  • HCS
  • ms(2)04445
  • pDMc01
  • pDMc02
  • THC4
  • wu:fk52b01
  • zgc:86706
Alternatives
anti-Mouse (Murine) Cytochrome C antibody for Immunocytochemistry
Reactivity
Cow (Bovine), Mouse (Murine)
307
230
172
94
62
56
28
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28
25
24
19
15
8
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2
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
237
137
7
2
Clonality
Polyclonal
Conjugate
This Cytochrome C antibody is un-conjugated
20
14
10
7
7
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5
5
5
5
5
5
5
5
5
5
2
1
1
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1
Application
Western Blotting (WB)
277
157
138
81
69
67
48
34
19
11
11
8
6
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4
4
4
3
3
2
1
1
1
1
1
1
1
1
Supplier
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Immunogen Bovine cytochrome c
Blocking Peptide Blocking peptide for this product available: ABIN412698
Isotype IgG
Specificity The cytochrome c antibody detects the 12 kDa cytochrome c from mouse and bovine samples.
Purification Affinity purified
Alternative Name Cytochrome C (CYCS Antibody Abstract)
Background Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases.
Synonyms: CYCS, CYC
Gene ID 109892891
UniProt P62894
Research Area Apoptosis/Necrosis, Metabolism
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western blotting (0.5-4 μg/mL).
Mouse small intestine lysate can be used as a positive control.
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Cytochrome c polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Cytochrome C antibody (Cytochrome C, Somatic) (ABIN223077) Western blot analysis of cytochrome c with mouse small intestine tissue lysate.
Product cited in: Zhao, Chen, Lu, Dong, Wang, Bi, Wu, Guo, Wu, Guo: "TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 11, pp. 4133-41, 2008 (PubMed).

Lan, Gorke, Rau, Zeisel, Hildt, Himmelsbach, Carvajal-Yepes, Huber, Wakita, Schmitt-Graeff, Royer, Blum, Fischer, Baumert: "Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4926-35, 2008 (PubMed).

Kuhn, Chen, Voorhees, Strader, Shenk, Sun, Demo, Bennett, van Leeuwen, Chanan-Khan, Orlowski: "Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma." in: Blood, Vol. 110, Issue 9, pp. 3281-90, 2007 (PubMed).

Machiya, Shibata, Yamauchi, Hirama, Wada, Inoue, Abe, Takabatake, Sata, Kubota: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).