Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae) (FIS1) antibody

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Antigen
Synonyms TTC11, Ttc11, 2010003O14Rik
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(1), (1), (1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(1)
Pubmed 5 references available
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Quantity 100 μL
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Immunogen Synthetic peptide surrounding amino acid 143 of human Fis1
Blocking Peptide Blocking peptide for this product available: Fis1 peptide (ABIN412734)
Isotype IgG
Specificity The antibody recognizes Fis1 of human, mouse, and rat origins.
Purification Affinity purified
Background HFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been sμggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
Synonyms: hFis1 , TTC11 , H_NH0132A01.6 , CGI-135
Gene ID 51024
UniProt Q9Y3D6
Application Notes Western blotting (1:100-500), Immunoprecipitation (1:50-200), Immunohistochemistry (1:100) and Immunofluorescence (1:20-100).
However, the optimal concentrations should be determined individually.
Comment

Suggested positive control: IHC: Tonsil tissue
Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Buffer 100 μL purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 20 % glycerol, 0.2 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Jheng, Tsai, Guo et al.: "Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle." in: Molecular and cellular biology, Vol. 32, Issue 2, pp. 309-19, 2011 (PubMed).

Thomas, McCoy, Blackinton et al.: "DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy." in: Human molecular genetics, Vol. 20, Issue 1, pp. 40-50, 2010 (PubMed).

Sandebring, Thomas, Beilina et al.: "Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1." in: PLoS ONE, Vol. 4, Issue 5, pp. e5701, 2009 (PubMed).

Karbowski, Neutzner, Youle: "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division." in: The Journal of cell biology, Vol. 178, Issue 1, pp. 71-84, 2007 (PubMed).

Wasiak, Zunino, McBride: "Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 439-50, 2007 (PubMed).

Catalog No. ABIN223209
$341.00
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