FIS1 antibody (Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae))

Details for Product anti-FIS1 Antibody No. ABIN223210, Supplier: Log in to see
Antigen
  • TTC11
  • Ttc11
  • 2010003O14Rik
  • fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
  • tetratricopeptide repeat domain 11
  • fission 1 (mitochondrial outer membrane) homolog (yeast)
  • FIS1
  • LOC100362813
  • Fis1
Alternatives
anti-Human FIS1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
88
31
30
Host
Rabbit
48
39
Clonality
Polyclonal
Conjugate
This FIS1 antibody is un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
81
46
36
21
18
14
10
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Synthetic peptide surrounding amino acid 143 of human Fis1
Blocking Peptide Blocking peptide for this product available: ABIN412734
Isotype IgG
Specificity The antibody recognizes Fis1 of human, mouse, and rat origins.
Purification Affinity purified
Alternative Name Fis1 (FIS1 Antibody Abstract)
Background HFis1 is a novel molecule that was discovered as part of the mammalian fission machinery. Fis 1 has been sμggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
Synonyms: hFis1 , TTC11 , H_NH0132A01.6 , CGI-135
Gene ID 51024
UniProt Q9Y3D6
Pathways Positive Regulation of Endopeptidase Activity
Application Notes Western blotting (1-4 μg/mL). Per research's feedback, the antibody can also be used in immunofluorescence. However, the optimal concentrations should be determined individually. The antibody recognizes Fis1 of human, mouse, and rat origins.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Fission 1 (Mitochondrial Outer Membrane) Homolog (S. Cerevisiae) (FIS1) antibody (ABIN223210) Western blot analysis of Fis-1 expression with Jurkat Cell lysates.
Product cited in: Ganapathy, Perry, Tawfik, Smith, Perry, Roon, Bozard, Ha, Smith: "Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 8, pp. 5551-8, 2011 (PubMed).

Jheng, Tsai, Guo, Kuo, Chang, Su, Chang, Tsai: "Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle." in: Molecular and cellular biology, Vol. 32, Issue 2, pp. 309-19, 2011 (PubMed).

Javadov, Rajapurohitam, Kili?, Hunter, Zeidan, Said Faruq, Escobales, Karmazyn: "Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition." in: Basic research in cardiology, Vol. 106, Issue 1, pp. 99-109, 2010 (PubMed).

Thomas, McCoy, Blackinton, Beilina, van der Brug, Sandebring, Miller, Maric, Cedazo-Minguez, Cookson: "DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy." in: Human molecular genetics, Vol. 20, Issue 1, pp. 40-50, 2010 (PubMed).

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