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Serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) antibody

Details for Product No. ABIN223215, Supplier: Log in to see
Antigen
  • SERPINH1
  • DKFZp468B197
  • BERF-1
  • Cbp1
  • Cbp2
  • Hsp47
  • J6
  • Serpinh2
  • colligin
  • gp46
  • HSP47
  • AsTP3
  • CBP1
  • CBP2
  • OI10
  • PPROM
  • RA-A47
  • SERPINH2
  • astp3
  • cbp1
  • cbp2
  • hsp47
  • pig14
  • pprom
  • ra-a47
  • serpinh2
Reactivity
Chicken, Human, Mouse (Murine), Rat (Rattus)
93
41
23
7
2
2
2
1
1
1
Host
Rabbit
66
43
Clonality
Polyclonal
Conjugate
Un-conjugated
6
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
94
38
29
23
19
17
11
10
6
4
2
2
Supplier
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Immunogen Synthetic peptide surrounding amino acid 407 of human HSP47
Blocking Peptide Blocking peptide for this product available: ABIN412790
Isotype IgG
Specificity The antibody recognizes 47 kDa Hsp47 of human, mouse, rat, and chick origins.
Purification Affinity purified
Alternative Name Hsp47 (SERPINH1 Antibody Abstract)
Background Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. HSP47 is a molecule expressed constitutively in cells that synthesizes collagen. HSP47 is a procollagen-specific molecular chaperon that resides in the endoplasmic reticulum of procollagen-producing cells and is essential for secretion of procollagen from cells. Significantly, HSP47 plays a vital role in folding and assembling collagen. HSP47 is also known as colligin 1, serpinh1, collagen-binding protein 1 (CBP1) and gp46. The human HSP 47 gene encodes a 47 kDa protein.
Synonyms: SERPINH1 , AsTP3 , CBP1 , CBP2 , HSP47 , PIG14 , RA-A47 , PPROM , colligen , colligin-2 , SERPINH2
Gene ID 12406
UniProt P19324
Research Area Signaling, Heat Shock Proteins
Pathways
Application Notes Western blotting (0.5-4 μg/mL), Immunoprecipitation (10-20 μg/mL) and Immunohistochemistry (10-20 μg/mL) in frozen or paraffin embedded tissues.
Mouse small intestine tissue lysate can be used as a positive control.
However, the optimal concentrations should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) Protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) (SERPINH1) antibody (ABIN223215) Western blot analysis of Hsp47 expression in mouse small intestine tissue lysate.
Product cited in: Cheng, Pollock, Mahimkar et al.: "Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 11, pp. 1898-900, 2006 (PubMed).