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Details for Product No. ABIN223287

Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody

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Antigen
Synonyms GP145-TrkB, TRKB, trk-B, Tkrb, trkB, AI848316, C030027L06Rik, RATTRKB1, TRKB1, Trk-B, TrkB, trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN223287
Quantity 100 µg
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide surrounding AA 810 of human TrkB
Isotype IgG
Specificity Detects TrkB in samples from human/rat origins
Purification Affinity purified
Alternative Name TrkB
Background Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF.
Gene ID 25054
Research Area Cancer
Application Notes The antibody can be used in Western blotting (0.5-4 µg/mL).
Based on researchers feedback, it also works well in immunofluorescence (5-10 µg/mL).
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Jang, Liu, Pradoldej et al.: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010 (PubMed).

Jang, Liu, Yepes et al.: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010 (PubMed).

Shen, Ghai, Sompol et al.: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012 (PubMed).

Jang, Liu, Chan et al.: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010 (PubMed).

Alternatives for antigen "Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2)", type "Antibodies"
Hosts (178), (13), (7), (4), (4)
Reactivities (175), (148), (145), (27), (25), (24), (12), (1)
Applications (134), (67), (63), (40), (39), (25), (8), (8), (5), (4), (2), (2), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (29), (29), (17), (15), (13), (6), (6), (6), (5), (5), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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