Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody

Details for Product No. ABIN223287
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Antigen
Synonyms trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb, TRKB, GP145-TrkB, trk-B, AI848316, C030027L06Rik, Tkrb, trkB, RATTRKB1, TRKB1, Trk-B, TrkB
Reactivity
Human, Rat (Rattus)
(232), (161), (159), (27), (25), (24), (12), (1), (1)
Host
Rabbit
(226), (20), (6), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(168), (97), (86), (40), (37), (29), (9), (6), (5), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 100 μg
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Catalog No. ABIN223287
319.00 $
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  • +1 404 474 4654
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Immunogen Synthetic peptide surrounding AA 810 of human TrkB
Isotype IgG
Specificity Detects TrkB in samples from human/rat origins
Purification Affinity purified
Alternative Name TrkB
Background Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF.
Gene ID 25054
Research Area Cancer
Application Notes The antibody can be used in Western blotting (0.5-4 µg/mL).
Based on researchers feedback, it also works well in immunofluorescence (5-10 µg/mL).
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody Western Blot Analysis of trkB expression in HL-60 Cell Lysate.
Product cited in: Jang, Liu, Pradoldej et al.: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010 (PubMed).

Jang, Liu, Yepes et al.: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010 (PubMed).

Shen, Ghai, Sompol et al.: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012 (PubMed).

General Jang, Liu, Chan et al.: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010 (PubMed).

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