anti-TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2)

Details for Product anti-NTRK2 Antibody No. ABIN223287
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Synonyms trkb, trkb-b, xtrkb, si:ch211-220b11.1, trkB2, NTRK2, ntrk2, gp145-trkb, TRKB, GP145-TrkB, trk-B, AI848316, C030027L06Rik, Tkrb, trkB, RATTRKB1, TRKB1, Trk-B, TrkB
Chicken, Human, Mouse (Murine), Rat (Rattus)
(262), (159), (156), (4), (2), (2), (2), (2), (1)
(252), (22), (13), (5), (3)
This TRKB antibody is un-conjugated
(6), (6), (6), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(207), (112), (104), (44), (30), (30), (9), (9), (6), (3), (2), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide surrounding amino acid 810 of human TrkB
Isotype IgG
Specificity Detects TrkB in samples from human/rat origins
Purification Affinity purified
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.
Synonyms: NTRK2 , GP145-TrkB , TRKB , Trk-B , tyrosine receptor kinase
Gene ID 25054
UniProt Q63604
Research Area Cancer
Pathways RTK Signaling
Application Notes The antibody can be used in Western blotting (0.5-4 µg/mL).
Based on researchers feedback, it also works well in immunofluorescence (5-10 µg/mL).
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (ABIN223287) Western Blot Analysis of trkB expression in HL-60 Cell Lysate.
Product cited in: Shen, Ghai, Sompol et al.: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012 (PubMed).

Jang, Liu, Chan et al.: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010 (PubMed).

Jang, Liu, Yepes et al.: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010 (PubMed).

Jang, Liu, Pradoldej et al.: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010 (PubMed).

Catalog No. ABIN223287
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