TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2)

Details for Product anti-NTRK2 Antibody No. ABIN223287, Supplier: Log in to see
Antigen
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic tyrosine kinase, receptor, type 2
  • neurotrophic tyrosine kinase, receptor, type 2b
  • NTRK2
  • ntrk2-b
  • ntrk2b
  • ntrk2-a
  • ntrk2
  • Ntrk2
Alternatives
anti-Chicken TRKB antibody for Immunofluorescence
Reactivity
Chicken, Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This TRKB antibody is un-conjugated
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Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen Synthetic peptide surrounding amino acid 810 of human TrkB
Blocking Peptide Blocking peptide for this product available: ABIN412957
Isotype IgG
Specificity Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa. .
Purification Affinity purified
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.
Synonyms: NTRK2 , GP145-TrkB , TRKB , Trk-B , tyrosine receptor kinase
Gene ID 25054
UniProt Q63604
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
Application Notes Western blotting (0.5-4 μg/mL), immunofluorescence (5-10 μg/mL). However, the optimal concentrations should be determined individually. Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.2 mg/mL) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody (ABIN223287) Western Blot Analysis of trkB expression in HL-60 Cell Lysate.
Product cited in: Shen, Ghai, Sompol, Liu, Cao, Iuvone, Ye: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012 (PubMed).

Jang, Liu, Pradoldej, Tosini, Chang, Iuvone, Ye: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010 (PubMed).

Jang, Liu, Chan, France, Sayeed, Tang, Lin, Xiao, Andero, Chang, Ressler, Ye: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010 (PubMed).

Jang, Liu, Yepes, Shepherd, Miller, Liu, Wilson, Xiao, Blanchi, Sun, Ye: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010 (PubMed).

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