Voltage-Dependent Anion Channel 1 (VDAC1) antibody

Details for Product No. ABIN223288
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Antigen
Synonyms vdac1, VDAC1, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, PORIN, VDAC-1, AL033343, Vdac5, fa13f11, wu:fa13f11, zgc:85830
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(127), (51), (51), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(84), (47)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(122), (61), (43), (38), (23), (19), (10), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Immunogen Synthetic peptide surrounding amino acid 189 of human VDAC
Isotype IgG
Specificity Detects approx. 31 kDa VDAC in samples from human/mouse/rat/bovine/rabbit/pig origins
Purification Affinity purified
Alternative Name VDAC/Porin (VDAC1 Antibody Abstract)
Background The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is thoμght to form the major pores throμgh which adenine nucleotides are transferred throμgh the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is thoμght to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
Synonyms: VDAC1, VDAC-1 , MGC111064 , hVDAC1, Porin
Gene ID 7416
UniProt P21796
Research Area Signaling, Metabolism, Organelles, Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal concentrations should be determined individually.
Comment

Suggested positive control:
Western Blot: 3T3 cell lysate. IHC: Liver tissue

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Voltage-Dependent Anion Channel 1 (VDAC1) antibody Western blot analysis of VDAC/Porinwith 3T3 cell lysate.
Product cited in: Bortner, Scoltock, Sifre et al.: "Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes." in: The Journal of biological chemistry, Vol. 287, Issue 9, pp. 6284-95, 2012 (PubMed).

Validation Images
Catalog No. ABIN223288
319.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
319.00 $

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