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Details for Product No. ABIN223288

Voltage-Dependent Anion Channel 1 (VDAC1) antibody

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Antigen
Synonyms PORIN, VDAC-1, Vdac5, AL033343, fa13f11, zgc:85830, wu:fa13f11, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, vdac1, VDAC1
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Cow (Bovine), Rabbit, Pig (Porcine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN223288
Quantity 100 µg
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide surrounding AA 189 of human VDAC
Isotype IgG
Specificity Detects approx. 31 kDa VDAC in samples from human/mouse/rat/bovine/rabbit/pig origins
Purification Affinity purified
Alternative Name VDAC/Porin
Background The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is thought to form the major pores through which adenine nucleotides are transferred through the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
Gene ID 7416
Research Area Signaling, Metabolism, Organelles, Apoptosis/Necrosis
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Bortner, Scoltock, Sifre et al.: "Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes." in: The Journal of biological chemistry, Vol. 287, Issue 9, pp. 6284-95, 2012 (PubMed).

Alternatives for antigen "Voltage-Dependent Anion Channel 1 (VDAC1)", type "Antibodies"
Hosts (43), (28)
Reactivities (65), (38), (37), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (69), (33), (26), (20), (14), (6), (2), (2), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (7), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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