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Voltage-Dependent Anion Channel 1 (VDAC1) antibody

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Antigen
Synonyms vdac1, VDAC1, 5076, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, ATVDAC1, T22N4.9, T22N4_9, voltage dependent anion channel 1, PORIN, VDAC-1, AL033343, Vdac5, fa13f11, wu:fa13f11, zgc:85830
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(141), (57), (54), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(98), (47)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(130), (65), (45), (41), (27), (25), (11), (8), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 100 μg
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Immunogen Synthetic peptide surrounding amino acid 189 of human VDAC
Blocking Peptide Blocking peptide for this product available: ABIN412963
Isotype IgG
Specificity The antibody recognizes ~31 kDa VDAC/Porin from samples of human, mouse, rat, bovine, pig, and rabbit origins.
Purification Affinity purified
Alternative Name VDAC/Porin (VDAC1 Antibody Abstract)
Background The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is thoμght to form the major pores throμgh which adenine nucleotides are transferred throμgh the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is thoμght to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
Synonyms: VDAC1, VDAC-1 , MGC111064 , hVDAC1, Porin
Gene ID 7416
UniProt P21796
Research Area Signaling, Metabolism, Organelles, Apoptosis/Necrosis
Application Notes Western blotting (0.5-4 μg/mL) and Immunohistochemistry (2.5 μg/mL).
However, the optimal concentrations should be determined individually.
Comment

Suggested positive control: Western Blot: 3T3 cell lysate. IHC: Liver tissue
Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-VDAC/Porin polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Voltage-Dependent Anion Channel 1 (VDAC1) antibody (ABIN223288) Western blot analysis of VDAC/Porinwith 3T3 cell lysate.
Product cited in: Ghelli, Tropeano, Calvaruso et al.: "The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2141-51, 2013 (PubMed).

Bortner, Scoltock, Sifre et al.: "Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes." in: The Journal of biological chemistry, Vol. 287, Issue 9, pp. 6284-95, 2012 (PubMed).

Catalog No. ABIN223288
$319.00
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