Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) antibody

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Antigen
Synonyms CYP19, CYP19A1, ARO, ARO1, CPV1, CYAR, CYPXIX, P-450AROM, Aromatase, Cyp19, Cyp19a, p450arom, CYP19P1, Ar, ArKO, Int-5, Int5, P450AROM, P450 arom, aro, cyp19, cyp19a, p450arom-A
Reactivity
Chicken, Cow (Bovine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
(131), (55), (38), (17), (8), (7), (5), (5), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(89), (29), (20)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(106), (47), (39), (34), (23), (17), (5), (4), (4), (3), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen Synthetic peptide surrounding amino acid 385 of human Aromatase
Blocking Peptide Blocking peptide for this product available: Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) peptide (ABIN412600)
Isotype IgG
Specificity A 55 kDa band can be detected, corresponding to the expected molecular weight of Aromatase.
Alternative Name Aromatase (CYP19A1 Antibody Abstract)
Background Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, fertility, and carcinogenesis. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.
Synonyms: 25147 , Cyp19a1, Aromatase , Cyp19 , p450arom , ARO1, ARO 1, CPV, CYP19A1 , MGC104309
Gene ID 1588
UniProt P11511
Research Area Cancer, Endocrine system, Enzymes
Application Notes Western blotting (0.5-4 μg/mL), Immunohistochemistry (10-20 μg/mL).
Jurkat cell lysate can be used as a positive control.
However, the optimal concentrations should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Aromatase polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) antibody (ABIN223293) Western blot analysis of Aromatase in human brain cell lysate.
Product cited in: El Hajj Chehadeh, Dreumont, Willekens et al.: "Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups." in: American journal of physiology. Endocrinology and metabolism, Vol. 307, Issue 11, pp. E1009-19, 2014 (PubMed).

Yonezawa, Higashi, Yoshioka et al.: "Distribution of aromatase and sex steroid receptors in the baculum during the rat life cycle: effects of estrogen during the early development of the baculum." in: Biology of reproduction, Vol. 85, Issue 1, pp. 105-12, 2011 (PubMed).

Hirayama, Sawai, Moriyasu et al.: "Excess estrogen sulfoconjugation as the possible cause for a poor sign of parturition in pregnant cows carrying somatic cell clone fetuses." in: Reproduction (Cambridge, England), Vol. 136, Issue 5, pp. 639-47, 2008 (PubMed).

Bukulmez, Hardy, Carr et al.: "Inflammatory status influences aromatase and steroid receptor expression in endometriosis." in: Endocrinology, Vol. 149, Issue 3, pp. 1190-204, 2008 (PubMed).

Sun, Yan, Jacobson et al.: "Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 293, Issue 3, pp. R1239-46, 2007 (PubMed).

Catalog No. ABIN223293
$363.00
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