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Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) antibody

Details for Product No. ABIN223293, Supplier: Log in to see
Antigen
  • CYP19
  • CYP19A1
  • ARO
  • ARO1
  • CPV1
  • CYAR
  • CYPXIX
  • P-450AROM
  • Aromatase
  • Cyp19
  • Cyp19a
  • p450arom
  • CYP19P1
  • Ar
  • ArKO
  • Int-5
  • Int5
  • P450AROM
  • P450 arom
  • aro
  • cyp19
  • cyp19a
  • p450arom-A
Reactivity
Chicken, Cow (Bovine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
127
54
37
18
9
6
5
5
3
3
3
2
2
1
1
1
1
1
1
Host
Rabbit
86
28
19
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
100
41
34
33
23
15
4
4
3
2
Supplier
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Immunogen Synthetic peptide surrounding amino acid 385 of human Aromatase
Blocking Peptide Blocking peptide for this product available: ABIN412600
Isotype IgG
Specificity A 55 kDa band can be detected, corresponding to the expected molecular weight of Aromatase.
Alternative Name Aromatase (CYP19A1 Antibody Abstract)
Background Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, fertility, and carcinogenesis. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.
Synonyms: 25147 , Cyp19a1, Aromatase , Cyp19 , p450arom , ARO1, ARO 1, CPV, CYP19A1 , MGC104309
Gene ID 1588
UniProt P11511
Research Area Cancer, Endocrine system, Enzymes
Application Notes Western blotting (0.5-4 μg/mL), Immunohistochemistry (10-20 μg/mL).
Jurkat cell lysate can be used as a positive control.
However, the optimal concentrations should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Aromatase polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) antibody (ABIN223293) Western blot analysis of Aromatase in human brain cell lysate.
Product cited in: El Hajj Chehadeh, Dreumont, Willekens et al.: "Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups." in: American journal of physiology. Endocrinology and metabolism, Vol. 307, Issue 11, pp. E1009-19, 2014 (PubMed).

Yonezawa, Higashi, Yoshioka et al.: "Distribution of aromatase and sex steroid receptors in the baculum during the rat life cycle: effects of estrogen during the early development of the baculum." in: Biology of reproduction, Vol. 85, Issue 1, pp. 105-12, 2011 (PubMed).

Hirayama, Sawai, Moriyasu et al.: "Excess estrogen sulfoconjugation as the possible cause for a poor sign of parturition in pregnant cows carrying somatic cell clone fetuses." in: Reproduction (Cambridge, England), Vol. 136, Issue 5, pp. 639-47, 2008 (PubMed).

Bukulmez, Hardy, Carr et al.: "Inflammatory status influences aromatase and steroid receptor expression in endometriosis." in: Endocrinology, Vol. 149, Issue 3, pp. 1190-204, 2008 (PubMed).

Sun, Yan, Jacobson et al.: "Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERalpha knockout mice: role of aromatase." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 293, Issue 3, pp. R1239-46, 2007 (PubMed).