Histone Deacetylase 5 (HDAC5) antibody

Details for Product No. ABIN223300
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Antigen
Synonyms HDAC5, DKFZp459O115, HD5, NY-CO-9, AI426555, Hdac4, mHDA1, mKIAA0600, ATHDA5, HDA5, MAF19.7, MAF19_7, histone deacetylase 5, Hd6, Hdac5, Sfc6, mHDA2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(161), (75), (35)
Host
Rabbit
(153), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(136), (97), (74), (24), (21), (16), (7), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 100 μg
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Immunogen Synthetic peptide surrounding amino acid 575 of human HDAC-5
Isotype IgG
Specificity Detects approx. 125 kDa HDAC5
Purification Affinity purified
Alternative Name HDAC5 (HDAC5 Antibody Abstract)
Background Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
Synonyms: HD5 , FLJ90614 , KIAA0600 , NY-CO-9
Gene ID 10014
UniProt Q9UQL6
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
Based on researchers feedback, the antibody also works well in Immunoprecipitation (20 µg/mL), and Immunohistochemistry (20 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 5 (HDAC5) antibody Western blot analysis of HDAC5 expression in Jurkat cell lysate.
Product cited in: Cao, Li, Zhu et al.: "The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity." in: The Journal of biological chemistry, Vol. 288, Issue 47, pp. 34181-9, 2013 (PubMed).

Yamaguchi, Chakraborty, Pasek et al.: "Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules." in: American journal of physiology. Heart and circulatory physiology, Vol. 300, Issue 6, pp. H2187-95, 2011 (PubMed).

Validation Images
Catalog No. ABIN223300
341.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
341.00 $

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