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Histone Deacetylase 10 (HDAC10) (N-Term) antibody

Details for Product No. ABIN223305, Supplier: Log in to see
Antigen
  • HDAC10
  • wu:fd19e10
  • zgc:55652
  • MGC115178
  • histone deacetylase 10
  • HD10
  • AW548891
  • Hd10
Epitope
N-Term
24
14
2
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
105
26
26
3
Host
Rabbit
70
35
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
84
35
33
14
12
11
8
6
4
2
1
1
Supplier
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Immunogen Synthetic peptide near the N-terminus of human HDAC-10
Blocking Peptide Blocking peptide for this product available: ABIN412763
Isotype IgG
Specificity The antibody recognizes 74 kDa HDAC-10 of human, mouse, and rat origins.
A 55 kDa cleavage fragment can also be detected in mouse and rat tissue lysates.
Purification Affinity purified
Alternative Name HDAC10 (HDAC10 Antibody Abstract)
Background HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results sμggest that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Synonyms: HD10 , Histone deacetylase 10
Gene ID 83933
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blotting (0.5-4 μg/mL),
However, the optimal concentrations should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibody (ABIN223305) Western blot analysis of HDAC-10 expression. Lane Jurkat Cells Lane Mouse Intestine L...
Product cited in: Ai, Wang, Dar et al.: "HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1963-72, 2009 (PubMed).

Fiskus, Rao, Fernandez et al.: "Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells." in: Blood, Vol. 112, Issue 7, pp. 2896-905, 2008 (PubMed).

Bali, Pranpat, Bradner et al.: "Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26729-34, 2005 (PubMed).