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Histone Deacetylase 10 (HDAC10) (N-Term) antibody

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Synonyms HDAC10, wu:fd19e10, zgc:55652, MGC115178, histone deacetylase 10, HD10, AW548891, Hd10
(24), (14), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(107), (26), (26), (3)
(72), (35)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(87), (36), (33), (24), (12), (11), (9), (6), (5), (2), (2), (1)
Pubmed 3 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide near the N-terminus of human HDAC-10
Blocking Peptide Blocking peptide for this product available: ABIN412763
Isotype IgG
Specificity The antibody recognizes 74 kDa HDAC-10 of human, mouse, and rat origins.
A 55 kDa cleavage fragment can also be detected in mouse and rat tissue lysates.
Purification Affinity purified
Alternative Name HDAC10 (HDAC10 Antibody Abstract)
Background HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results sμggest that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Synonyms: HD10 , Histone deacetylase 10
Gene ID 83933
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blotting (0.5-4 μg/mL),
However, the optimal concentrations should be determined individually.

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibody (ABIN223305) Western blot analysis of HDAC-10 expression. Lane Jurkat Cells Lane Mouse Intestine L...
Product cited in: Ai, Wang, Dar et al.: "HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1963-72, 2009 (PubMed).

Fiskus, Rao, Fernandez et al.: "Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells." in: Blood, Vol. 112, Issue 7, pp. 2896-905, 2008 (PubMed).

Bali, Pranpat, Bradner et al.: "Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26729-34, 2005 (PubMed).

Catalog No. ABIN223305
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