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Details for Product No. ABIN223305

Histone Deacetylase 10 (HDAC10) (N-Term) antibody

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Synonyms HD10, Hd10, AW548891, HDAC10, wu:fd19e10, zgc:55652, MGC115178, histone deacetylase 10
»Alternatives N-Term
»Alternatives Rabbit
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN223305
Quantity 100 µg
269.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide near the N-terminus of human HDAC-10
Isotype IgG
Purification Affinity purified
Alternative Name HDAC10
Background HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggest that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Gene ID 83933
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors, Wnt Signaling
Application Notes The antibody can be used in Western blotting (0.5-4 µg/mL),
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Bali, Pranpat, Bradner et al.: "Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26729-34, 2005 (PubMed).

Fiskus, Rao, Fernandez et al.: "Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells." in: Blood, Vol. 112, Issue 7, pp. 2896-905, 2008 (PubMed).

Ai, Wang, Dar et al.: "HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1963-72, 2009 (PubMed).

Alternatives for antigen "Histone Deacetylase 10 (HDAC10)", type "Antibodies"
Hosts (42), (20)
Reactivities (61), (23), (23), (12), (12)
Applications (52), (16), (16), (13), (10), (9), (5), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (8), (2), (1), (1), (1)