Histone Deacetylase 10 (HDAC10) (N-Term) antibody

Details for Product No. ABIN223305
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Antigen
Synonyms HDAC10, wu:fd19e10, zgc:55652, MGC115178, histone deacetylase 10, HD10, AW548891, Hd10
Epitope
N-Term
(11), (10), (6), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Rabbit
(74), (26), (26), (12), (12), (1)
Host
Rabbit
(54), (21)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(65), (26), (25), (13), (10), (9), (5), (2), (1)
Pubmed 3 references available
Quantity 100 µg
Options
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Catalog No. ABIN223305
269.50 $
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Immunogen Synthetic peptide near the N-terminus of human HDAC-10
Isotype IgG
Purification Affinity purified
Alternative Name HDAC10
Background HDAC family are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggest that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
Gene ID 83933
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors, Wnt Signaling
Application Notes The antibody can be used in Western blotting (0.5-4 µg/mL),
However the optimal concentrations should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 10 (HDAC10) (N-Term) antibody Western blot analysis of HDAC-10 expression. Lane Jurkat Cells Lane Mouse Intestine Lane Rat Brain
Product cited in: Bali, Pranpat, Bradner et al.: "Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors." in: The Journal of biological chemistry, Vol. 280, Issue 29, pp. 26729-34, 2005 (PubMed).

Fiskus, Rao, Fernandez et al.: "Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells." in: Blood, Vol. 112, Issue 7, pp. 2896-905, 2008 (PubMed).

Ai, Wang, Dar et al.: "HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1963-72, 2009 (PubMed).

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