MAPK8IP1 antibody (Mitogen-Activated Protein Kinase 8 Interacting Protein 1)

Details for Product anti-MAPK8IP1 Antibody No. ABIN223343, Supplier: Log in to see
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
66
47
39
Host
Rabbit
71
2
1
Clonality
Polyclonal
Conjugate
This MAPK8IP1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
58
31
17
13
9
7
4
3
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Synthetic peptide from mouse JIP1
Blocking Peptide Blocking peptide for this product available: ABIN412803
Isotype IgG
Specificity The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins.
Reactivity to other species has not been tested.
Purification Affinity purified
Alternative Name JIP1 (MAPK8IP1 Antibody Abstract)
Background JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.
Synonyms: JIP 1 , JNK , IB1 , IB 1 , MAPK8IP 1 , MAPK8IP1 , Mitogen activated protein kinase 8 ,
Gene ID 19099
UniProt Q9WVI9
Application Notes Western blotting (0.5-4 μg/mL). However, the optimal concentrations should be determined individually. The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins. In human sample, a ~110 kDa isoform can also be observed. Reactivity to other species has not been tested.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) protein A purified rabbit anti-JIP1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) antibody (ABIN223343) Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2...
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