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Low Density Lipoprotein Receptor-Related Protein (LRP) antibody

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Antigen
Reactivity
Mouse (Murine), Human
(4), (4), (3)
Host
Mouse
(3), (1)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(4)
Pubmed 7 references available
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Quantity 100 μg
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Shipping to United States ( )
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Immunogen Synthetic peptide derived from human LRP-6
Blocking Peptide Blocking peptide for this product available: ABIN412819
Clone 1A12
Isotype IgG2b kappa
Specificity Detects full length and a proteolytic fragment of LRP-6.
Purification Affinity purified
Alternative Name LRP-5/6
Background LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.
Synonyms: LRP-5, LRP-6, LDL-related protein, LDL receptor, Axin, beta-catenin
Gene ID 4041
UniProt O75197
Application Notes Western blot analysis (1-2 μg/mL).
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: USA

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 100 μg (1 mg/mL) purified antibody in 10 mM Tris-glycine ( pH 7.0), 0.15 M NaCl, 25 % glycerol, 0.5 % BSA, and 0.01 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Caverzasio, Manen: "Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells." in: Endocrinology, Vol. 148, Issue 11, pp. 5323-30, 2007 (PubMed).

Caira, Stock, Gleason et al.: "Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation." in: Journal of the American College of Cardiology, Vol. 47, Issue 8, pp. 1707-12, 2006 (PubMed).

Rajamannan, Subramaniam, Caira et al.: "Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway." in: Circulation, Vol. 112, Issue 9 Suppl, pp. I229-34, 2005 (PubMed).

Ai, Holmen, Van Hul et al.: "Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling." in: Molecular and cellular biology, Vol. 25, Issue 12, pp. 4946-55, 2005 (PubMed).

Cappuccio, Calderone, Busceti et al.: "Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 10, pp. 2647-57, 2005 (PubMed).

Berasain, García-Trevijano, Castillo et al.: "Novel role for amphiregulin in protection from liver injury." in: The Journal of biological chemistry, Vol. 280, Issue 19, pp. 19012-20, 2005 (PubMed).

Caricasole, Ferraro, Iacovelli et al.: "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37024-31, 2003 (PubMed).

Catalog No. ABIN223471
$407.00
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