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IL 18 antibody (Interleukin 18)

Details for Product anti-IL18 Antibody No. ABIN223550, Supplier: Log in to see
Antigen
  • ChIL-18
  • Igif
  • IGIF
  • IL-1g
  • Il-18
  • IL-18
  • IL1F4
  • IL18
Reactivity
Human
138
37
23
15
10
5
3
2
1
1
1
Host
Rabbit
155
45
14
2
1
1
Clonality
Polyclonal
Conjugate
This IL 18 antibody is un-conjugated
22
14
10
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
145
113
48
23
20
15
14
12
8
3
2
1
1
Supplier
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Immunogen Synthetic peptide surrounding amino acid 41 of human IL-18
Blocking Peptide Blocking peptide for this product available: ABIN412797
Isotype IgG
Purification Affinity purified
Alternative Name IL-18 (IL18 Antibody Abstract)
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: IL-18, IL18, IL 18, Interluekin-18, Interluekin 18, interluekin
Gene ID 3606
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Western blot analysis (0.5-4 μg/mL).
Recombinant human IL-18 can be used as a positive control (Cat.
However, the optimal conditions should be determined individually.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-human IL-18 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-IL 18 antibody (Interleukin 18) (ABIN223550) Western blot analysis of human IL-18 expression with Jurkat cell lysate (Lane 1 & 2)
Product cited in: Zhang, Xu, Ma, Wu, Wang, Zhou, Han: "Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3517-24, 2013 (PubMed).

Terme, Ullrich, Aymeric, Meinhardt, Desbois, Delahaye, Viaud, Ryffel, Yagita, Kaplanski, Prévost-Blondel, Kato, Schultze, Tartour, Kroemer, Chaput, Zitvogel: "IL-18 induces PD-1-dependent immunosuppression in cancer." in: Cancer research, Vol. 71, Issue 16, pp. 5393-9, 2011 (PubMed).

Galmbacher, Heisig, Hotz, Wischhusen, Galmiche, Bergmann, Gentschev, Goebel, Rapp, Fensterle: "Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression." in: PLoS ONE, Vol. 5, Issue 3, pp. e9572, 2010 (PubMed).

Nour, Yeung, Santambrogio, Boyden, Stanley, Brojatsch: "Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages." in: Infection and immunity, Vol. 77, Issue 3, pp. 1262-71, 2009 (PubMed).

Squires, Muehlbauer, Brojatsch: "Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 34260-7, 2007 (PubMed).