Interleukin 18 (IL18) antibody

Details for Product No. ABIN223550
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Antigen
Synonyms Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18
Reactivity
Human
(91), (36), (32), (21), (12), (1), (1), (1)
Host
Rabbit
(106), (25), (4), (2), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (7), (6), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(95), (63), (38), (23), (20), (15), (14), (11), (6), (6), (3), (2), (2), (2)
Pubmed 4 references available
Quantity 100 µg
Options
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Catalog No. ABIN223550
269.50 $
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Immunogen Synthetic peptide surrounding AA 41 of human IL-18
Isotype IgG
Purification Affinity purified
Alternative Name IL-18
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Gene ID 3606
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes The antibody can be used for Western blot analysis (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
Recombinant human IL-18 can be used as a positive control is also available separately.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Interleukin 18 (IL18) antibody Western blot analysis of human IL-18 expression with Jurkat cell lysate (Lane 1 & 2)
Product cited in: Squires, Muehlbauer, Brojatsch: "Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 34260-7, 2007 (PubMed).

Nour, Yeung, Santambrogio et al.: "Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages." in: Infection and immunity, Vol. 77, Issue 3, pp. 1262-71, 2009 (PubMed).

Terme, Ullrich, Aymeric et al.: "IL-18 induces PD-1-dependent immunosuppression in cancer." in: Cancer research, Vol. 71, Issue 16, pp. 5393-9, 2011 (PubMed).

General Galmbacher, Heisig, Hotz et al.: "Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression." in: PLoS ONE, Vol. 5, Issue 3, pp. e9572, 2010 (PubMed).

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