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IL 18 antibody (Interleukin 18)

Details for Product anti-IL18 Antibody No. ABIN223550, Supplier: Login to see New
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Synonyms Igif, Il-18, IL-18, IGIF, ChIL-18, IL-1g, IL1F4, IL18
(128), (38), (24), (15), (10), (5), (3), (2), (1), (1), (1)
(154), (38), (13), (2), (1), (1)
This IL 18 antibody is un-conjugated
(22), (14), (10), (2), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(141), (110), (45), (24), (17), (15), (14), (8), (5), (4), (2), (2), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide surrounding amino acid 41 of human IL-18
Blocking Peptide Blocking peptide for this product available: ABIN412797
Isotype IgG
Purification Affinity purified
Alternative Name IL-18 (IL18 Antibody Abstract)
Background Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important role in cell-mediated immune responses.
Synonyms: IL-18, IL18, IL 18, Interluekin-18, Interluekin 18, interluekin
Gene ID 3606
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Western blot analysis (0.5-4 μg/mL).
Recombinant human IL-18 can be used as a positive control (Cat.
However, the optimal conditions should be determined individually.

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-human IL-18 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-IL 18 antibody (Interleukin 18) (ABIN223550) Western blot analysis of human IL-18 expression with Jurkat cell lysate (Lane 1 & 2)
Product cited in: Zhang, Xu, Ma et al.: "Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 7, pp. 3517-24, 2013 (PubMed).

Terme, Ullrich, Aymeric et al.: "IL-18 induces PD-1-dependent immunosuppression in cancer." in: Cancer research, Vol. 71, Issue 16, pp. 5393-9, 2011 (PubMed).

Galmbacher, Heisig, Hotz et al.: "Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression." in: PLoS ONE, Vol. 5, Issue 3, pp. e9572, 2010 (PubMed).

Nour, Yeung, Santambrogio et al.: "Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages." in: Infection and immunity, Vol. 77, Issue 3, pp. 1262-71, 2009 (PubMed).

Squires, Muehlbauer, Brojatsch: "Proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 34260-7, 2007 (PubMed).

Catalog No. ABIN223550
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