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Details for Product No. ABIN223760

CD207 Molecule, Langerin (CD207) antibody

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Synonyms CLEC4K, RGD1565913, CD207
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 11 references available
Catalog no. ABIN223760
Quantity 0.1 mg
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Immunogen recombinant human langerin
Clone 929F3-01
Isotype IgG2a
Specificity Human Langerin
Purification Purified
Alternative Name CD207 / Langerin
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. Human Langerin is involved in the processing of mycobacterial glycolipids leading to antigen presentation to CD1a-restricted T cells. Human Langerin binds the gp120 glycoprotein of HIV.(Valladeau J et al, 2002 J Immunol, 168 : 782-792) (Douillard P et al, 2005 J Invest Dermatol, 125: 983-994)
Research Area CD Antigens
Application Notes Usage Recommendation: This monoclonal antibody may be used between 5-20 ug/ml .
Restrictions For Research Use only
Format Liquid
Buffer 100 ug in 200ul Tris-NaCl pH 8
Storage -20 °C
Dubrac, Stoitzner, Pirkebner et al.: "Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4362-72, 2007 (PubMed).

Zimmerli, Hauser: "Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1." in: The Journal of investigative dermatology, Vol. 127, Issue 10, pp. 2381-90, 2007 (PubMed).

Stoecklinger, Grieshuber, Scheiblhofer et al.: "Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 2, pp. 886-93, 2007 (PubMed).

Kaplan, Li, Jenison et al.: "Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells." in: The Journal of experimental medicine, Vol. 204, Issue 11, pp. 2545-52, 2007 (PubMed).

Poulin, Henri, de Bovis et al.: "The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells." in: The Journal of experimental medicine, Vol. 204, Issue 13, pp. 3119-31, 2007 (PubMed).

Bursch, Wang, Igyarto et al.: "Identification of a novel population of Langerin+ dendritic cells." in: The Journal of experimental medicine, Vol. 204, Issue 13, pp. 3147-56, 2007 (PubMed).

Flacher, Douillard, Auit-Yahia et al.: "Expression of langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains." in: Immunology, Vol. 123, Issue 3, pp. 339-47, 2008 (PubMed).

Stoitzner, Green, Jung et al.: "Inefficient presentation of tumor-derived antigen by tumor-infiltrating dendritic cells." in: Cancer immunology, immunotherapy : CII, Vol. 57, Issue 11, pp. 1665-73, 2008 (PubMed).

Shklovskaya, Roediger, Fazekas de St Groth: "Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 1, pp. 418-30, 2008 (PubMed).

Tripp, Haid, Flacher et al.: "The lymph vessel network in mouse skin visualised with antibodies against the hyaluronan receptor LYVE-1." in: Immunobiology, Vol. 213, Issue 9-10, pp. 715-28, 2008 (PubMed).

Maddaluno, Verbrugge, Martinoli et al.: "The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells." in: The Journal of experimental medicine, Vol. 206, Issue 3, pp. 623-35, 2009 (PubMed).

Alternatives for antigen "CD207 Molecule, Langerin (CD207)", type "Antibodies"
Hosts (59), (47), (28)
Reactivities (106), (98), (67), (10), (10)
Applications (109), (38), (29), (25), (10), (8), (7), (7), (7), (5), (4), (1), (1), (1)
Conjugates (19), (19), (17), (16), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (2)