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Details for Product No. ABIN233779

p48-DDB2 (AA 419-427), (C-Term) antibody

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Antigen
Epitope
AA 419-427, C-Term
Reactivity
Human
Host
Rabbit
Clonality Polyclonal
Application
Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 1 reference available
Catalog no. ABIN233779
Quantity 100 µL
Price
361.90 $   Plus shipping costs $45.00 and if applicable $26.40 dry ice
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 419-427 of Human DDB2 coupled to KLH.
Characteristics Concentration Definition: by Refractometry
Purification Antiserum
Background DDB2 is also known as Damage-specific DNA binding protein 2, DDB p48 subunit, DDBb, UV-damaged DNA-binding protein 2 and UV-DDB 2.  The DDB2 gene encodes the small subunit (p48) of DNA damage-binding protein, which is a heterodimer, composed of a large (p127 DDB1) and a small subunit.  The DDB2 subunit appears to be required for DNA binding.  This nuclear protein functions in nucleotide-excision repair resulting from UV-damaged DNA by binding to pyrimidine dimers.  Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE).  XP-E is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.  However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the large subunit.
Synonyms: damage-specific DNA binding protein 2 antibody, UV-DDB 2 antibody
Gene ID 1643
NCBI Accession 4557515
UniProt Q92466
Application Notes This antibody reacts with human DDB2 by western blot and immunoprecipitation.  The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using 293T, and others).  Coimmunoprecipitation of related proteins has not been tested.  A 47.8 kDa band corresponding to human DDB2 is detected.  Most cell lines expressing DDB2 can be used as a positive control.  Researchers should determine optimal titers for other applications.
Restrictions For Research Use only
Format Liquid
Concentration 85 mg/mL
Preservative Sodium azide
Storage -20 °C
Abbas, Sivaprasad, Terai et al.: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, 2008 (PubMed).

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