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TP53BP2 antibody (Internal Region)

TP53BP2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN233802
  • Target See all TP53BP2 Antibodies
    TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
    Binding Specificity
    • 10
    • 9
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 54
    • 23
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 2
    Rabbit
    Clonality
    • 44
    • 10
    Polyclonal
    Conjugate
    • 23
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TP53BP2 antibody is un-conjugated
    Application
    • 46
    • 22
    • 9
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Characteristics
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP2.
    Isotype
    IgG
    Top Product
    Discover our top product TP53BP2 Primary Antibody
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 125 kDa in size corresponding to ASPP2 by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.4 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))
    Alternative Name
    ASPP2 (TP53BP2 Products)
    Synonyms
    53BP2 antibody, ASPP2 antibody, BBP antibody, P53BP2 antibody, PPP1R13A antibody, TP53BP2 antibody, AI746547 antibody, Tp53bp2 antibody, X98550 antibody, Trp53bp2 antibody, wu:fa09h08 antibody, wu:fb04e08 antibody, zgc:85720 antibody, tumor protein p53 binding protein 2 antibody, tumor protein p53 binding protein 2 L homeolog antibody, tumor protein p53 binding protein, 2b antibody, transformation related protein 53 binding protein 2 antibody, tumor protein p53 binding protein, 2 antibody, tumor protein p53 binding protein, 2a antibody, TP53BP2 antibody, tp53bp2.L antibody, tp53bp2 antibody, tp53bp2b antibody, Trp53bp2 antibody, Tp53bp2 antibody, tp53bp2a antibody
    Background
    ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
    Synonyms: Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody
    Gene ID
    7159, 112799849
    UniProt
    Q13625
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