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8-Hydroxyguanosine (8-OHDG) antibody

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(27), (2), (1), (1), (1)
(15), (14)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
(21), (13), (8), (5), (4), (4), (2), (2), (2), (1)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 4 to 5 Business Days
Immunogen 8-hydroxyguanosine (oh8G)-BSA and -casein conjugates
Clone 15A3
Isotype IgG2b
Specificity Recognizes 8-hydroxy-2'-deoxyguanosine (oh8dG), 8-hydroxyguanine (oh8G), and 8-hydroxyguanosine (oh8G). These are markers of oxidative damage to DNA and RNA.
Characteristics MAb to 8-Hydroxyguanosine, Monoclonal antibody to 8-Hydroxyguanosine
Purification Protein G Chromatography. Ascites
Alternative Name 8-Hydroxyguanosine
Target Type Chemical
Application Notes Suitable for use in ELISA and immunohistochemistry (PLP-fixed sections) to detect the markers of oxidative damage to DNA and RNA. May also be used on immunoaffinity columns to isolate oxidative DNA damage adducts from biological fluids. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer TBS, pH 7.4, 0.1 % Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage 4 °C
Storage Comment Store at 2-8 °C.
Background publications Salganik, Albright, Rodgers et al.: "Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice." in: Carcinogenesis, Vol. 21, Issue 5, pp. 909-14, 2000 (PubMed).

Cui, Holmes, Liu: "Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia." in: Journal of neurochemistry, Vol. 73, Issue 3, pp. 1164-74, 1999 (PubMed).

Nunomura, Perry, Pappolla et al.: "RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 6, pp. 1959-64, 1999 (PubMed).

Park, Shigenaga, Degan et al.: "Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 8, pp. 3375-9, 1992 (PubMed).

Catalog No. ABIN234190
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