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8-Hydroxyguanosine (8-OHDG) antibody
| Antigen | 8-Hydroxyguanosine (8-OHDG) |
| Clonality | Monoclonal (15A3) |
| Host |
 Alternatives Mouse |
| Application |
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|
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4 references available |
| Catalog no. | ABIN234190 |
| Quantity | 100ug (1mg/ml (OD280nm)) (Variants) |
| Price | 458.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | 8-Hydroxyguanosine |
| Immunogen | 8-hydroxyguanosine (oh8G)-BSA and ?casein conjugates |
| Format | Purified, Liquid |
| Isotype | IgG2a (Matching secondary antibodies) |
| Clone | 15A3 |
| Description | MAb to 8-Hydroxyguanosine Monoclonal Antibody to 8-Hydroxyguanosine |
| Specificity | Recognizes 8-hydroxy-2?-deoxyguanosine (oh8dG), 8-hydroxyguanine (oh8G), and 8-hydroxyguanosine (oh8G). These are markers of oxidative damage to DNA and RNA. |
Application Details
| Application Notes | Suitable for use in ELISA and immunohistochemistry (PLP-fixed sections) to detect the markers of oxidative damage to DNA and RNA. May also be used on immunoaffinity columns to isolate oxidative DNA damage adducts from biological fluids. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. |
| Concentration | 1mg/ml (OD280nm) |
| Purification | Protein G chromatography. Source: Ascites |
| Buffer | TBS, pH 7.4. Preservative: 0.1% Sodium azide |
| Storage | Store at 2-8°C. DO NOT FREEZE! |
| Restrictions | For Research Use only |
Publications
| Publications |
Park, Shigenaga, Degan et al.: "Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 8, pp. 3375-9, 1992 (PubMed).
Nunomura, Perry, Pappolla et al.: "RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 6, pp. 1959-64, 1999 (PubMed). Cui, Holmes, Liu: "Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia." in: Journal of neurochemistry, Vol. 73, Issue 3, pp. 1164-74, 1999 (PubMed). Salganik, Albright, Rodgers et al.: "Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice." in: Carcinogenesis, Vol. 21, Issue 5, pp. 909-14, 2000 (PubMed). |
Alternatives
Alternatives for antigen "8-Hydroxyguanosine (8-OHDG)", type "Antibodies"
| Hosts | Mouse (13), Goat (8) |
| Applications | ELISA (19), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Affinity Chromatography (AC) (2), Immunocytochemistry (ICC) (1), Immunofluorescence (IF) (1), Western Blotting (WB) (1) |
