B-Cell CLL/lymphoma 3 (BCL3) antibody

Details for Product No. ABIN234363
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Human, Mouse (Murine)
(81), (60), (16), (1)
(62), (45), (8)
Clonality (Clone)
Monoclonal ()
(10), (10), (9), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(88), (34), (32), (23), (16), (14), (13), (12), (10), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN234363
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Immunogen Recombinant mouse Bcl-3-6His
Clone B325H
Isotype IgG
Specificity Recognizes human and mouse Bcl-3. The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the I-kappa-B subfamily of inhibitors of NF-kappa-B transcription factors. Bcl-3 does not have DNA-binding activity, but it interacts with NF-kappa-B1 and NF-kappa-B2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NF-kappa-B family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney and testes.
Characteristics MAb to Bcl-3, Monoclonal antibody to Bcl-3
Purification PEG precipitation. Ascites
Alternative Name Bcl-3
Research Area Cancer
Application Notes Suitable for use in Western blot (use as 2 µg/mL) and ELISA. In Western blot, a band of approximately 46-52 kDa is detected. Positive control: Jurkat T cell lysate. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage -20 °C
Storage Comment Upon receipt, store at -20 °C.
General Mitchell, Hildeman, Kedl et al.: "Immunological adjuvants promote activated T cell survival via induction of Bcl-3." in: Nature immunology, Vol. 2, Issue 5, pp. 397-402, 2001 (PubMed).

Watanabe, Iwamura, Shinoda et al.: "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation." in: The EMBO journal, Vol. 16, Issue 12, pp. 3609-20, 1997 (PubMed).

Nolan, Fujita, Bhatia et al.: "The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner." in: Molecular and cellular biology, Vol. 13, Issue 6, pp. 3557-66, 1993 (PubMed).

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