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Integrin beta 2 antibody (ITGB2)

Details for Product anti-ITGB2 Antibody No. ABIN234544, Supplier: Login to see
Antigen
  • ITGB2
  • 2E6
  • AI528527
  • Cd18
  • LAD
  • LCAMB
  • Lfa1
  • MF17
  • CD18
  • LFA-1
  • MAC-1
  • MFI7
  • AI256028
  • LTbetaR
  • Ltar
  • TNF-R-III
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNFRrp
  • Tnfbr
  • Tnfrsf3
  • D12S370
  • LT-BETA-R
  • TNFR3
  • TNFRSF3
Alternatives
anti-Human Integrin beta 2 antibody for Functional Studies
Reactivity
Human
427
214
111
26
24
7
6
3
3
2
2
2
2
2
2
2
1
1
Host
Mouse
302
186
155
5
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 2 antibody is un-conjugated
100
75
55
19
9
7
6
5
4
3
3
3
3
3
3
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
426
242
197
107
84
83
63
54
40
35
17
11
7
6
4
3
2
2
1
1
1
Supplier
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Immunogen Purified gp90-160 complex
Clone 7E4
Isotype IgG1
Specificity CD18 antigen is a 90 kDa integral membrane glycoprotein, beta-2 chain, which can be non-covalently associated with each of the alpha chains of the beta-2 integrin family: alpha-L (gp160 - CD11a), alpha-M (gp155 - CD11b) or alpha-X (gp130 - CD11c). This molecule is involved in cell-cell interactions. It is strongly expressed by practically all types of leukocytes (platelets are negative). Clone 7E4 recognizes a group 1 epitope on this beta-2 integrin chain. Blocks beta-2 integrin dependent cell adhesion. (It efficiently inhibits phorbol ester-induced cell aggregation. It is also able to inhibit the spontaneous aggregation of EBV-B cells.
Characteristics MAb to CD18 LFA-1, Monoclonal antibody to CD18
Purification Ascites
Alternative Name CD18 (ITGB2 Antibody Abstract)
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling
Application Notes Pan leukocyte marker. Fluorescent microscopy or flow cytometry: 2 µg/5x105 cells/test. Immunohistochemistry: Suggested working dilution: 1:25 to 1:50 Only suitable on frozen sections or cell smears. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 1 mL of distilled water.
Buffer Lyophilized from PBS containing 1 mg/mL BSA.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles. The addition of 0.1 % (w/v) sodium azide is recommended for storage of the Reconstituted form for up to one month at 2-8 °C.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized product at 2-8 °C. After reconstitution, aliquot and store at -28 °C.
Background publications Schmitt, Souteyrand, Brochier et al.: "Phenotype of cells involved in mycosis fungoides and S" in: Acta dermato-venereologica, Vol. 62, Issue 3, pp. 193-9, 1982 (PubMed).

Kishimoto, Hollander, Roberts et al.: "Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency." in: Cell, Vol. 50, Issue 2, pp. 193-202, 1987 (PubMed).

Kishimoto, OConnor, Lee et al.: "Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family." in: Cell, Vol. 48, Issue 4, pp. 681-90, 1987 (PubMed).