Integrin beta 2 (ITGB2) antibody

Details for Product No. ABIN234544
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Antigen
Synonyms ITGB2, 2E6, AI528527, Cd18, LAD, LCAMB, Lfa1, MF17, CD18, LFA-1, MAC-1, MFI7, AI256028, LTbetaR, Ltar, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, Tnfrsf3, D12S370, LT-BETA-R, TNFR3, TNFRSF3
Reactivity
Human
(257), (168), (99), (61), (53), (46), (36), (24), (1)
Host
Mouse
(179), (114), (103), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(55), (40), (29), (14), (10), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Application
Flow Cytometry (FACS)
(262), (136), (119), (63), (45), (41), (40), (40), (38), (27), (15), (6), (3), (3), (2)
Pubmed 3 references available
Quantity 0.2 mg
Options
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Catalog No. ABIN234544
417.27 $
Plus shipping costs $45.00

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Immunogen Purified gp90-160 complex
Clone 7E4
Specificity CD18 antigen is a 90kDa integral membrane glycoprotein, beta-2 chain, which can be non-covalently associated with each of the alpha chains of the beta-2 integrin family: alpha-L (gp160 - CD11a), alpha-M (gp155 - CD11b) or alpha-X (gp130 - CD11c). This molecule is involved in cell-cell interactions. It is strongly expressed by practically all types of leukocytes (platelets are negative). Clone 7E4 recognizes a group 1 epitope on this beta-2 integrin chain. Blocks beta-2 integrin dependent cell adhesion. (It efficiently inhibits phorbol ester-induced cell aggregation. It is also able to inhibit the spontaneous aggregation of EBV-B cells.
Characteristics MAb to CD18 LFA-1, Monoclonal antibody to CD18
Purification Ascites
Alternative Name CD18
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes Pan leukocyte marker. Fluorescent microscopy or flow cytometry: 2 µg/5x105 cells/test. Immunohistochemistry: Suggested working dilution: 1:25 to 1:50 Only suitable on frozen sections or cell smears. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 1mL of distilled water.
Buffer Lyophilized from PBS containing 1mg/ml BSA.
Handling Advice Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage of the Reconstituted form for up to one month at 2-8°C.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized product at 2-8°C. After reconstitution, aliquot and store at -20°C.
General Kishimoto, OConnor, Lee et al.: "Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family." in: Cell, Vol. 48, Issue 4, pp. 681-90, 1987 (PubMed).

Kishimoto, Hollander, Roberts et al.: "Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency." in: Cell, Vol. 50, Issue 2, pp. 193-202, 1987 (PubMed).

Schmitt, Souteyrand, Brochier et al.: "Phenotype of cells involved in mycosis fungoides and S" in: Acta dermato-venereologica, Vol. 62, Issue 3, pp. 193-9, 1982 (PubMed).

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