CD3 (CD3) antibody

Details for Product No. ABIN234588
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Antigen
Synonyms CD3
Reactivity
Human
(471), (131), (50), (31), (25), (19), (15), (5), (5), (5), (4), (4), (2), (2)
Host
Mouse
(494), (92), (78), (41)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(113), (63), (59), (27), (11), (7), (7), (6), (6), (5), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(509), (117), (95), (94), (89), (85), (51), (44), (34), (19), (10), (6), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 100 tests
Options
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Catalog No. ABIN234588
393.07 $
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  • +1 404 474 4654
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Immunogen Peripheral blood lymphocytes
Clone UCHT1
Isotype IgG1
Specificity Reacts with the epsilon chain of the CD3 complex.(5) CD3 is associated with the T cell receptor (TcR) on T lymphocytes and is involved in the recognition of peptides bound to the major histocompatibility complex (MHC) during the immune response.(2) The CD3 antigen is expressed by mature T lymphocytes and by a subset of thymocytes.(1, 3)
Characteristics MAb to CD3, Monoclonal antibody to CD3
Purification Purified
Alternative Name CD3
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Application Notes Studies of CD3 expressing lymphocytes and intracellular studies of the CD3 epsilon chain. Flow cytometry: 20 µL/5x105 cells or 100 µL of whole blood. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Concentration 12.5 µg/mL (sufficient for 100 Tests)
Buffer PBS containing 2 mg/mL BSA, 0.1 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage 4 °C
Storage Comment Store at 2-8 °C.
General le Gouvello, Manceau, Sobel: "Serine 16 of stathmin as a cytosolic target for Ca2+/calmodulin-dependent kinase II after CD2 triggering of human T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 3, pp. 1113-22, 1998 (PubMed).

Torres, Alcover, Zapata et al.: "TCR dynamics in human mature T lymphocytes lacking CD3 gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5947-55, 2003 (PubMed).

Arnett, Harrison, Wiley: "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 46, pp. 16268-73, 2004 (PubMed).

Demedts, Brusselle, Vermaelen et al.: "Identification and characterization of human pulmonary dendritic cells." in: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, 2005 (PubMed).

Lin, Liu, Chen et al.: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Rieux-Laucat, Hivroz, Lim et al.: "Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency." in: The New England journal of medicine, Vol. 354, Issue 18, pp. 1913-21, 2006 (PubMed).

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