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Low Density Lipoprotein Receptor-Related Protein (LRP), 515 kDa antibody

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Clonality (Clone)
Monoclonal ()
Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Immunogen Human LRP/alpha2 MR
Clone 8G1
Isotype IgG1
Fragment Chain kappa
Specificity Specifically reacts with the 515 kDa alpha-chain of human LRP/alpha2 MR expressed in certain cell types. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in the CNS, fibroblasts, smooth muscle cells and monocyte-derived foam cells in atherosclerotic lesions of arterial walls. Will block a2M binding
Characteristics MAb to Low Density LRP (515 kDa), Monoclonal antibody to Human Low Density Lipoprotein Receptor-Related Protein (LRP), 515 kDa
Purification Protein A Chromatography. Ascites
Application Notes Western blot (non-reducing conditions): 1-5 µg/mL Immunohistochemistry using paraffin and frozen sections: 1-10 µg/mL Flow cytometry will recognize an epitope on the extracellular domain. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer 0.05 M Sodium phosphate containing 0.5 M Sodium chloride, pH 7.4.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage -80 °C
Storage Comment Upon receipt, aliquot and store at -70 °C.
Background publications Rebeck, Reiter, Strickland et al.: "Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions." in: Neuron, Vol. 11, Issue 4, pp. 575-80, 1993 (PubMed).

Strickland, Kounnas, Argraves: "LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 9, Issue 10, pp. 890-8, 1995 (PubMed).

Coukos, Gåfvels, Wisel et al.: "Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts." in: The American journal of pathology, Vol. 144, Issue 2, pp. 383-92, 1994 (PubMed).

Wolf, Lopes, VandenBerg et al.: "Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain." in: The American journal of pathology, Vol. 141, Issue 1, pp. 37-42, 1992 (PubMed).

Catalog No. ABIN235782

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