Paired Helical Filaments (pSer396) antibody

Antigen: Paired Helical Filaments

Binding Site: pSer396

Clonality: Monoclonal (PHF13)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN235971

Additional Information

Format: Liquid

Isotype: IgG2b

Clone: PHF13

Description: MAb to Paired Helical Filament Monoclonal Antibody to Human Paired Helical Filaments, Phosphorylated at Serine 396

Specificity: Reactive to paired helical filaments with phosphorylation at Ser396.

Application Details

Application Notes: Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific (OD280nm)

Purification: Protein A chromatography. Source: Ascites

Buffer: PBS.

Storage: Upon receipt, store undiluted at -20°C to -80°C. Do not store antibody diluted below 50ug/ml in the absence of protein (i.e. add 2% BSA).

Restrictions: For Research Use only

Publications

Bramblett, Goedert, Jakes et al.: "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding." in: Neuron, Vol. 10, Issue 6, pp. 1089-99, 1993 (PubMed).

Hoffmann, Lee, Leight et al.: "Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites." in: Biochemistry, Vol. 36, Issue 26, pp. 8114-24, 1997 (PubMed).