Add to Basket
|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Podoplanin (PDPN) antibody
|Synonyms||T1A, GP36, GP40, Gp38, OTS8, T1A-2, AGGRUS, HT1A-1, PA2.26, T1a, OTS-8, T1alpha, RANDAM-2, E11, RTI40, T1-alpha, PDPN|
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro))
|5 references available|
|Price||715.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Immunogen||ORF Human Podoplanin ectodomain expressed in E. coli|
|Description||MAb to Podoplanin Monoclonal Antibody to Human Podoplanin|
|Specificity||Recognizes Human Podoplanin (gp36), a 36kDa type I cell membrane-associated glycoprotein, with a broad spectrum of distribution, being strongly expressed on the lymphatic endothelium found in lung, placenta and skeletal muscle and to a lesser extent in brain, kidney and liver. Podoplanin is absent on blood endothelium and therefore this antibody is able to distinguish between lymphatic vessels and blood vasculature.|
|Application Notes||Suitable for use in Immunohistochemistry, frozen and paraffin sections (0.75?2ug/ml). This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.|
|Purification||Ion exchange chromatography|
|Buffer||PBS. Preservative: 0.09% Sodium azide|
|Storage||Short term store at 2-8°C. Long term store at -20°C. Avoid multiple freeze/thaw cycles.|
|Restrictions||For Research Use only|
Zimmer, Oeffner, Von Messling et al.: "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium." in: The Biochemical journal, Vol. 341 ( Pt 2), pp. 277-84, 1999 (PubMed).
Dadras, Paul, Bertoncini et al.: "Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival." in: The American journal of pathology, Vol. 162, Issue 6, pp. 1951-60, 2003 (PubMed).
Schacht, Ramirez, Hong et al.: "T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema." in: The EMBO journal, Vol. 22, Issue 14, pp. 3546-56, 2003 (PubMed).
Kato, Fujita, Kunita et al.: "Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51599-605, 2003 (PubMed).
Misaki, Matsui, Matsuda: "Metabolic enzyme induction by HepG2 cells exposed to oxygenated and nonoxygenated polycyclic aromatic hydrocarbons." in: Chemical research in toxicology, Vol. 20, Issue 2, pp. 277-83, 2007 (PubMed).