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PRNP antibody (Prion Protein) (AA 93-109)

Details for Product anti-PRNP Antibody No. ABIN236109, Supplier: Log in to see
Antigen
  • AA960666
  • AI325101
  • AltPrP
  • ASCR
  • BIMP2
  • CARMA2
  • CD230
  • CJD
  • cjd
  • GSS
  • KURU
  • MGC84114
  • p27-30
  • prion
  • PRIP
  • Prn
  • Prn-i
  • Prn-p
  • PRNP
  • prp
  • Prp
  • PrP
  • PRP
  • prp(c)
  • prP27-30
  • PrP27-30
  • PrP33-35C
  • prP33-35C
  • PrP
  • PRPC
  • PrPc
  • PrPC
  • PrPSc
  • PSORS2
  • PSS1
  • Sinc
  • SIP
Epitope
AA 93-109
15
14
12
10
8
8
7
4
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Mammalian
125
68
52
48
47
5
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
104
70
27
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PRNP antibody is un-conjugated
9
7
6
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
136
100
57
50
22
14
11
9
5
5
5
4
2
Supplier
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Immunogen Full-length recombinant PrP
Clone 6D11
Isotype IgG2a
Specificity Reacts with both the PrPc and PrPsc forms. Reacts with human, bovine, sheep, mule deer, elk, mouse and hamster PrP.
Characteristics MAb to Prion Protein, Monoclonal antibody to Prion Protein (AA 93-109)
Purification Purified
Alternative Name Prion Protein (PRNP Antibody Abstract)
Application Notes Western blot ELISA Immunohistochemistry: Epitope must be re-exposed in fixed tissues by pretreatment using one of the following procedures: 70 % Formic acid for 10-30 minutes at room temperature. Hydrolytic autoclaving Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Do not store antibody diluted below 50 µg/mL in the absence of protein (i.e. add 2 % BSA).
Storage -20 °C
Storage Comment Upon receipt, store undiluted at -20 °C to -70 °C.
Background publications Adler, Zeiler, Kryukov, Kascsak, Rubenstein, Grossman: "Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro." in: Journal of molecular biology, Vol. 332, Issue 1, pp. 47-57, 2003 (PubMed).

Sigurdsson, Sy, Li, Scholtzova, Kascsak, Kascsak, Carp, Meeker, Frangione, Wisniewski: "Anti-prion antibodies for prophylaxis following prion exposure in mice." in: Neuroscience letters, Vol. 336, Issue 3, pp. 185-7, 2002 (PubMed).

Kascsak, Tonna-DeMasi, Fersko, Rubenstein, Carp, Powers: "The role of antibodies to PrP in the diagnosis of transmissible spongiform encephalopathies." in: Developments in biological standardization, Vol. 80, pp. 141-51, 1994 (PubMed).

Kascsak, Rubenstein, Merz, Tonna-DeMasi, Fersko, Carp, Wisniewski, Diringer: "Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins." in: Journal of virology, Vol. 61, Issue 12, pp. 3688-93, 1987 (PubMed).