anti-MAPT antibody (Microtubule-Associated Protein tau)

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Antigen
Alternatives
Reactivity
Human
(1083), (512), (482), (75), (19), (18), (15), (11), (9), (4), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(1035), (110), (11), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
This MAPT antibody is un-conjugated
(27), (9), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(980), (417), (317), (112), (94), (69), (44), (22), (15), (15), (12), (12), (12), (11), (6), (3), (2), (1), (1)
Pubmed 2 references available
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Quantity 0.2 mL
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Clone Tau46
Isotype IgG1
Specificity Reactive to amino acid sequence 404-441 of human Tau.
Characteristics MAb to Tau, Monoclonal antibody to Human Tau
Purification IgG fraction, Ammonium Sulfate precipitated and dialyzed tissue culture Supernatant Tissue culture
Alternative Name Tau (MAPT Antibody Abstract)
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Application Notes Suitable for use in ELISA, Western blot and Immunohistochemistry. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS.
Preservative Without preservative
Handling Advice Do not store antibody diluted below 50 µg/mL in the absence of protein (i.e. add 2 % BSA).
Storage -20 °C
Storage Comment Upon receipt, store undiluted at -20 °C to -80 °C.
General Hoffmann, Lee, Leight et al.: "Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites." in: Biochemistry, Vol. 36, Issue 26, pp. 8114-24, 1997 (PubMed).

Bramblett, Goedert, Jakes et al.: "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding." in: Neuron, Vol. 10, Issue 6, pp. 1089-99, 1993 (PubMed).