Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) antibody

Details for Product No. ABIN236934
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Antigen
Epitope
C-Term
(55), (37), (25), (23), (18), (5), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(277), (142), (138), (4), (4), (4), (1), (1), (1)
Host
Rabbit
(226), (33), (22), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (8), (7), (6), (6), (6), (6), (6), (6), (6), (5), (2), (2)
Application
Western Blotting (WB)
(196), (82), (78), (63), (60), (41), (23), (15), (8), (4), (4), (4), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 100 μg
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Immunogen Synthetic peptide corresponding to 14 AA near the carboxy terminal of human cbl (Genbank accession No. P22681)
Specificity Reacts with the carboxy terminus of human, mouse and rat c-Cbl. The mammalian cbl family of ubiquitin ligases consists of three homologs known as c-Cbl, Cbl-B and Cbl-3. Of the three known homologs in the cbl family this antibody reacts specifically with c-Cbl. Multiple isoforms of c-Cbl have been reported.
Characteristics Rabbit anti Cbl, Rabbit antibody to Casitas B-lineage Lymphoma Proto-oncogene (Cbl)
Purification Ion Exchange Chromatography
Alternative Name Casitas B-lineage Lymphoma Proto-oncogene (Cbl) (CBL Antibody Abstract)
Application Notes Suitable for use in Western blot (0.5-1 µg/mL). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.02 % Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store (up to one year) at 2-8 °C.
Expiry Date 12 months
General Swaminathan, Tsygankov: "The Cbl family proteins: ring leaders in regulation of cell signaling." in: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, 2006 (PubMed).

Thien, Langdon: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, 2005 (PubMed).

Weissman: "Themes and variations on ubiquitylation." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 3, pp. 169-78, 2001 (PubMed).

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Catalog No. ABIN236934
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