Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (N-Term) antibody

Antigen: Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2)

Synonyms: ICH1, NEDD2, CASP-2, ICH-1L, ICH-1L/1S, ICH-1, Nedd2, Caspase-2, xCaspase-2

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN236941

Additional Information

Alternative name: Caspase-2

Immunogen: 16 amino acid peptide from the amino-terminus of human Caspase-2 (Genbank accession No. P42575).

Format: Liquid

Description: Rabbit anti Caspase 2 (NT) Rabbit Antibody to Caspase-2, N-terminal

Specificity: Reacts with human and mouse Caspase-2. Depending on cell lines or tissues used, other cleavage products may be observed.

Application Details

Application Notes: Suitable for use in Western blot (1?g/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Ion exchange chromatography.

Buffer: PBS. Preservative: 0.02% Sodium Azide

Storage: Store at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).

Lassus, Opitz-Araya, Lazebnik: "Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization." in: Science (New York, N.Y.), Vol. 297, Issue 5585, pp. 1352-4, 2002 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005 (PubMed).