anti-Caspase 2 antibody (Caspase 2, Apoptosis-Related Cysteine Peptidase) (N-Term)

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Antigen
Alternatives
Epitope
N-Term
(26), (18), (13), (13), (7), (6), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(200), (62), (43), (6), (3), (2), (1)
Host
Rabbit
(167), (40), (13)
Clonality
Polyclonal
Conjugate
This Caspase 2 antibody is un-conjugated
(5), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(174), (93), (44), (32), (14), (12), (11), (11), (10), (9), (6), (4), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen 16 amino acid peptide from the amino-terminus of human Caspase-2 (Genbank accession No. P42575).
Specificity Reacts with human and mouse Caspase-2. Depending on cell lines or tissues used, other cleavage products may be observed.
Characteristics Rabbit anti Caspase 2 (NT), Rabbit antibody to Caspase-2, N-terminal
Purification Ion Exchange Chromatography.
Alternative Name Caspase-2 (CASP2 Antibody Abstract)
Research Area Apoptosis/Necrosis, Cancer, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
Application Notes Suitable for use in Western blot (1- g/mL). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2-8 °C.
General Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Lassus, Opitz-Araya, Lazebnik: "Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization." in: Science (New York, N.Y.), Vol. 297, Issue 5585, pp. 1352-4, 2002 (PubMed).

Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).