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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (Middle Region 2) antibody
|Synonyms||MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c, Mch6, AI115399, AW493809, Caspase-9, CASP9, LOC100101592|
Middle Region 2
Alternatives Western Blotting (WB)
|4 references available|
|Price||468.60 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Immunogen||Peptide corresponding to amino acids 299-318 of human caspase-9|
|Description||Rabbit anti Caspase-9 (I20) (Intermed. Domain 2) Rabbit Antibody to Caspase-9 (I20), Intermediate Domain 2|
|Specificity||Reacts with human caspase-9 and has no cross-reactivity with other members of the caspase family. Also known as Mch6/Apaf (IN2). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNF-alpha, TRAIL, anti-CD-95, FADD and TRADD. (4) Caspase-9 is expressed in a variety of human tissues. (1, 2)|
|Application Notes||Suitable for use in immunohistochemistry (2ug/ml) and Western blot (1:1,000-1:2,000). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.|
|Buffer||PBS. Preservative: 0.02% Sodium azide|
|Storage||Store (up to one year) at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.|
|Restrictions||For Research Use only|
Duan, Orth, Chinnaiyan et al.: "ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B." in: The Journal of biological chemistry, Vol. 271, Issue 28, pp. 16720-4, 1996 (PubMed).
Srinivasula, Fernandes-Alnemri, Zangrilli et al.: "The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32." in: The Journal of biological chemistry, Vol. 271, Issue 43, pp. 27099-106, 1996 (PubMed).
Li, Nijhawan, Budihardjo et al.: "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade." in: Cell, Vol. 91, Issue 4, pp. 479-89, 1997 (PubMed).
Pan, ORourke, Dixit: "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex." in: The Journal of biological chemistry, Vol. 273, Issue 10, pp. 5841-5, 1998 (PubMed).