Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (Extracellular Loop) antibody

Antigen: Chemokine (C-X-C Motif) Receptor 4 (CXCR4)

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Binding Site: Extracellular Loop

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN237103

Additional Information

Alternative name: CXCR4

Immunogen: Peptide corresponding to amino acids 182-196 in the second extracellular loop (EL) of human CXCR4.

Format: Liquid

Description: Rabbit anti CXCR4 Extracellular Loop Rabbit Antibody to CXCR4, Extracellular Loop

Specificity: Reacts with CXCR4 in human and mouse samples. Also known as fusion, LESTR and HUMSTR. CXCR4 is a principle co-receptor for T-cell trophic strains of HIV-1 fusion and entry of human white blood cells.

Synonyms: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, MGC108696, CXCR4, MGC128682, cxcr4, cxcr4-B, CXC-R4-B, CXCR-4-B, MGC52882, MGC130802, fb22, hm89, lap3, lcr1, npyr, whim, cd184, lestr, npy3r, npyrl, CXC-R4, CXCR-4, hsy3rr, npyy3r, xcxcr4, d2s201e

Application Details

Application Notes: Suitable for use in Western blot (1:500-1:1,000), immunoprecipitation and immunocytochemistry. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: 1mg/ml

Purification: Immunoaffinity chromatography

Buffer: PBS. Preservative: 0.02% Sodium azide

Storage: Store (up to 1 year) at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Feng, Broder, Kennedy et al.: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996 (PubMed).

Doranz, Rucker, Yi et al.: "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors." in: Cell, Vol. 85, Issue 7, pp. 1149-58, 1996 (PubMed).

Berson, Long, Doranz et al.: "A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains." in: Journal of virology, Vol. 70, Issue 9, pp. 6288-95, 1996 (PubMed).

Lapham, Ouyang, Chandrasekhar et al.: "Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines." in: Science (New York, N.Y.), Vol. 274, Issue 5287, pp. 602-5, 1996 (PubMed).

Endres, Clapham, Marsh et al.: "CD4-independent infection by HIV-2 is mediated by fusin/CXCR4." in: Cell, Vol. 87, Issue 4, pp. 745-56, 1997 (PubMed).

Brelot, Heveker, Pleskoff et al.: "Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity." in: Journal of virology, Vol. 71, Issue 6, pp. 4744-51, 1997 (PubMed).

Lu, Berson, Chen et al.: "Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6426-31, 1997 (PubMed).