IL-23.) (C-Term) antibody

Antigen: IL-23.)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN237701

Additional Information

Alternative name: Interleukin 23 (IL-23)

Immunogen: Synthetic peptide corresponding to 16 amino acids near the carboxy terminus of human IL-23 (Genbank accession No. NP_663634)

Format: Liquid

Description: Rabbit anti IL-23 (CT) Rabbit Antibody to Human Interleukin 23 (IL-23), C-terminal

Specificity: Reacts with the C-terminal of human and mouse IL-23. IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines(1). It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit(2). IL-23 is secreted by activated dendritic cells, macrophages, and monocytes.

Application Details

Application Notes: Suitable for use in Western blot (1?4ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Immunoaffinity chromatography

Buffer: PBS. Preservative: 0.02% Sodium azide

Storage: Store (up to 1 year) at 2-8(C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Oppmann, Lesley, Blom et al.: "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12." in: Immunity, Vol. 13, Issue 5, pp. 715-25, 2001 (PubMed).

Pirhonen, Matikainen, Julkunen: "Regulation of virus-induced IL-12 and IL-23 expression in human macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5673-8, 2002 (PubMed).

Sheibanie, Tadmori, Jing et al.: "Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 18, Issue 11, pp. 1318-20, 2004 (PubMed).

Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).

Hao, Shan: "Immune enhancement and anti-tumour activity of IL-23." in: Cancer immunology, immunotherapy : CII, Vol. 55, Issue 11, pp. 1426-31, 2006 (PubMed).