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Details for Product No. ABIN237702

Interleukin 23 (IL-23) (p19) (N-Term) antibody

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Antigen
Epitope
N-Term
Reactivity
Human
Host
Rabbit
Clonality Polyclonal
Application
Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN237702
Quantity 100 µg
Price
470.07 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen Synthetic peptide corresponding to 16 AA near the amino terminus of human IL-23 (Genbank accession No. AAH66268)
Specificity Reacts with the N-terminal of human and mouse IL-23. IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines(1). It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit(2). IL-23 is secreted by activated dendritic cells, macrophages, and monocytes.
Characteristics Rabbit anti IL-23 (NT) p19, Rabbit antibody to Human Interleukin 23 (IL-23) N-terminal (p19)
Purification Immuno Affinity Chromatography

Application Details

Handling References back to top
Application Notes Suitable for use in Western blot (1-2 µg/mL). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Storage 4 °C
Storage Comment Store (up to 1 year) at 2-8°C.
Expiry Date 12 months
Oppmann, Lesley, Blom et al.: "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12." in: Immunity, Vol. 13, Issue 5, pp. 715-25, 2001 (PubMed).

Pirhonen, Matikainen, Julkunen: "Regulation of virus-induced IL-12 and IL-23 expression in human macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5673-8, 2002 (PubMed).

Sheibanie, Tadmori, Jing et al.: "Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 18, Issue 11, pp. 1318-20, 2004 (PubMed).

Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).

Hao, Shan: "Immune enhancement and anti-tumour activity of IL-23." in: Cancer immunology, immunotherapy : CII, Vol. 55, Issue 11, pp. 1426-31, 2006 (PubMed).

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