Lysosomal-Associated Membrane Protein 2 (LAMP2) antibody

Antigen: Lysosomal-Associated Membrane Protein 2 (LAMP2)

Synonyms: LAMPB, CD107b, LGP110, Mac3, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, MGC82091, LAMP2, MGC127297, lamp2, DKFZp459J126

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN237777

Additional Information

Alternative name: Human Lysosome Associated Membrane Protein 2 (LAMP-2)

Immunogen: Synthetic peptide corresponding to 17 amino acids near the center of human LAMP-2 (Genbank accession No. NP_034815)

Format: Affinity-purified, Liquid

Description: Rabbit anti LAMP-2 Rabbit Antibody to Human Lysosome Associated Membrane Protein 2 (LAMP-2)

Specificity: Reacts with human and mouse LAMP-2. Despite its predicted size, LAMP-2 migrates at 115 kDa in SDS-PAGE.

Application Details

Application Notes: Suitable for use in Western blot (1 ? 2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Immunoaffinity chromatography

Buffer: PBS. Preservative: 0.02% Sodium Azide

Storage: Store (up to one year) at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Publications: Granger, Green, Gabel et al.: "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells." in: The Journal of biological chemistry, Vol. 265, Issue 20, pp. 12036-43, 1990 (PubMed).

Gough, Hatem, Fambrough: "The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c." in: DNA and cell biology, Vol. 14, Issue 10, pp. 863-7, 1995 (PubMed).

Kisen, Tessitore, Costelli et al.: "Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells." in: Carcinogenesis, Vol. 14, Issue 12, pp. 2501-5, 1994 (PubMed).

Tanaka, Guhde, Suter et al.: "Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice." in: Nature, Vol. 406, Issue 6798, pp. 902-6, 2000 (PubMed).

Kamada, Funakoshi, Shintani et al.: "Tor-mediated induction of autophagy via an Apg1 protein kinase complex." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1507-13, 2000 (PubMed).

Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, 2004 (PubMed).