P21-Activated Kinase 4 (PAK4) antibody

Details for Product No. ABIN237912
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Antigen
Synonyms AW555722, mKIAA1142, 5730488L07Rik
Reactivity
Human
(107), (55), (46), (38), (37), (37), (13), (1)
Host
Rabbit
(94), (16), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB)
(80), (52), (30), (28), (19), (8), (7), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN237912
Quantity 100 µg
Price
474.47 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 4 to 5 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to 13 AA near the center of human PAK4 (Genbank accession No. NP_005875)
Specificity Reacts to the middle region of human PAK4 The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac (1). PAK4 proteins are not activated by Cdc42/Rac binding. PAK4 is involved in cytoskeletal reorganization (2). Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development (3), and have also implicated PAK4 in anchorage-independent growth of tumor cells.
Characteristics Rabbit anti PAK4, Rabbit antibody to Human p21-Activated Kinase 4 (PAK4)
Purification Immuno Affinity Chromatography
Application Notes Suitable for use in Western blot (1-2 µg/mL). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Storage 4 °C
Storage Comment Store (up to 1 year) at 2-8°C.
Expiry Date 12 months
General Abo, Qu, Cammarano et al.: "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia." in: The EMBO journal, Vol. 17, Issue 22, pp. 6527-40, 1999 (PubMed).

Cotteret, Jaffer, Beeser et al.: "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5526-39, 2003 (PubMed).

Qu, Li, Novitch et al.: "PAK4 kinase is essential for embryonic viability and for proper neuronal development." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7122-33, 2003 (PubMed).

Li, Minden: "PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor." in: The Journal of biological chemistry, Vol. 280, Issue 50, pp. 41192-200, 2005 (PubMed).

Hosts (94), (16), (1)
Reactivities (107), (55), (46), (38), (37), (37), (13), (1)
Applications (80), (52), (30), (28), (19), (8), (7), (2), (1), (1)
Conjugates (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Epitopes (19), (12), (7), (6), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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