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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
P21-Activated Kinase 6 (PAK6) (Middle Region) antibody
|Synonyms||PAK5, 4732456M09, pak6, PAK6, DKFZp459O104|
Alternatives Western Blotting (WB)
|3 references available|
|Quantity||100ug (Lot specific)|
|Price||456.87 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Immunogen||Synthetic peptide corresponding to 13 amino acids near the center of human PAK6 (Genbank accession No. NP_064553)|
|Description||Rabbit anti PAK6 Rabbit Antibody to Human p21-Activated Kinase 6 (PAK6), Middle Region|
|Specificity||Reacts to the middle region of human PAK6. The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac (1). PAK6 proteins are not activated by Cdc42/Rac binding. PAK6 has been shown to be activated by MAP kinase kinase 6, and p38 MAP kinase (3), suggesting that PAK6 may play a role in the cellular response to stress-related signals.|
|Application Notes||Suitable for use in Western blot (1?2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.|
|Buffer||PBS. Preservative: 0.02% Sodium azide|
|Storage||Store (up to 1 year) at 2-8(C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.|
|Restrictions||For Research Use only|
Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).
Cotteret, Jaffer, Beeser et al.: "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5526-39, 2003 (PubMed).
Kaur, Liu, Gjoerup et al.: "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase." in: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3323-30, 2005 (PubMed).
|Reactivities||Human (53), Mouse (Murine) (31), Rat (Rattus) (30), Cow (Bovine) (21), Horse (Equine) (21), Pig (Porcine) (21), Chicken (20), Dog (Canine) (20), Cat (Feline) (1)|
|Applications||Western Blotting (WB) (28), Immunofluorescence (IF) (23), ELISA (19), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunoprecipitation (IP) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)|
|Epitopes||pSer165 (4), Linker Domain (3), Center (2), Internal Region (2), Middle Region (1), N-Term (1), pTyr716 (1)|