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P21-Activated Kinase 6 (PAK6) (Middle Region) antibody

Antigen

P21-Activated Kinase 6 (PAK6)
Synonyms PAK5, 4732456M09, pak6, PAK6, DKFZp459O104
Binding Site
Alternatives

Middle Region
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN237914
Quantity 100ug  (Lot specific)
Price 456.87 $   Plus shipping costs $45.00
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Additional Information
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Immunogen Synthetic peptide corresponding to 13 amino acids near the center of human PAK6 (Genbank accession No. NP_064553)
Format Liquid
Description Rabbit anti PAK6 Rabbit Antibody to Human p21-Activated Kinase 6 (PAK6), Middle Region
Specificity Reacts to the middle region of human PAK6. The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac (1). PAK6 proteins are not activated by Cdc42/Rac binding. PAK6 has been shown to be activated by MAP kinase kinase 6, and p38 MAP kinase (3), suggesting that PAK6 may play a role in the cellular response to stress-related signals.

Application Details
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Application Notes Suitable for use in Western blot (1?2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Concentration Lot specific
Purification Immunoaffinity chromatography
Buffer PBS. Preservative: 0.02% Sodium azide
Storage Store (up to 1 year) at 2-8(C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Cotteret, Jaffer, Beeser et al.: "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5526-39, 2003 (PubMed).

Kaur, Liu, Gjoerup et al.: "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase." in: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3323-30, 2005 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "P21-Activated Kinase 6 (PAK6)", type "Antibodies"
Hosts Rabbit (56)
Reactivities Human (53), Mouse (Murine) (31), Rat (Rattus) (30), Cow (Bovine) (21), Horse (Equine) (21), Pig (Porcine) (21), Chicken (20), Dog (Canine) (20), Cat (Feline) (1)
Applications Western Blotting (WB) (28), Immunofluorescence (IF) (23), ELISA (19), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunoprecipitation (IP) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pSer165 (4), Linker Domain (3), Center (2), Internal Region (2), Middle Region (1), N-Term (1), pTyr716 (1)