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Soluble Form Receptor Activator of NF-KappaB Ligand antibody
Western Blotting (WB)
|4 references available|
|Quantity||100ug (Lot specific)|
|Price||456.87 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 4 to 5 Business Days|
|Alternative name||Soluble form Receptor Activator of NF-kappaB Ligand (sRANK Ligand)|
|Immunogen||Synthetic peptide corresponding to 14 amino acids near the center of human sRANK-L (Genbank No. NP_005440)|
|Description||Rabbit anti sRANK Ligand Rabbit Antibody to Soluble form Receptor Activator of NF-kappaB Ligand (sRANK Ligand)|
|Specificity||Reacts to the middle region of human, mouse, and rat sRANK Ligand. The receptor activator of NF-kappaB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T-cell-dependent immune response, lymph node organogenesis and bone formation (1,2). RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor.|
|Application Notes||Suitable for use in Western blot (0.25?0.5 ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.|
|Buffer||PBS. Preservative: 0.02% Sodium azide|
|Storage||Store (up to 1 year) at 2-8(C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.|
|Restrictions||For Research Use only|
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Kong, Yoshida, Sarosi et al.: "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis." in: Nature, Vol. 397, Issue 6717, pp. 315-23, 1999 (PubMed).
Weitzmann, Cenci, Rifas et al.: "Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines." in: Blood, Vol. 96, Issue 5, pp. 1873-8, 2000 (PubMed).
Bharti, Takada, Shishodia et al.: "Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 6065-76, 2004 (PubMed).