Soluble Form Receptor Activator of NF-KappaB Ligand antibody

Antigen: Soluble Form Receptor Activator of NF-KappaB Ligand

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN238116

Additional Information

Alternative name: Soluble form Receptor Activator of NF-kappaB Ligand (sRANK Ligand)

Immunogen: Synthetic peptide corresponding to 14 amino acids near the center of human sRANK-L (Genbank No. NP_005440)

Format: Liquid

Description: Rabbit anti sRANK Ligand Rabbit Antibody to Soluble form Receptor Activator of NF-kappaB Ligand (sRANK Ligand)

Specificity: Reacts to the middle region of human, mouse, and rat sRANK Ligand. The receptor activator of NF-kappaB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T-cell-dependent immune response, lymph node organogenesis and bone formation (1,2). RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor.

Application Details

Application Notes: Suitable for use in Western blot (0.25?0.5 ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Immunoaffinity chromatography

Buffer: PBS. Preservative: 0.02% Sodium azide

Storage: Store (up to 1 year) at 2-8(C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Wong, Rho, Arron et al.: "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25190-4, 1997 (PubMed).

Kong, Yoshida, Sarosi et al.: "OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis." in: Nature, Vol. 397, Issue 6717, pp. 315-23, 1999 (PubMed).

Weitzmann, Cenci, Rifas et al.: "Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines." in: Blood, Vol. 96, Issue 5, pp. 1873-8, 2000 (PubMed).

Bharti, Takada, Shishodia et al.: "Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 6065-76, 2004 (PubMed).