TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibody

Antigen: TRAF Family Member-Associated NFKB Activator (TANK)

Synonyms: TRAF2, I-TRAF, TANK

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN238233

Additional Information

Alternative name: TRAF family member-associated NF-kappaB activator (TANK), N-terminal

Immunogen: Synthetic peptide corresponding to 14 amino acids near the amino terminal of human TANK (Genbank accession No. NP_004171)

Format: Affinity-purified, Liquid

Description: Rabbit anti TANK (NT) Rabbit Antibody to TRAF family member-associated NF-kappaB activator (TANK), N-terminal

Specificity: Reacts with the N-terminus of human TANK. TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction (1,2). Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. At least 2 isoforms of TANK are known to exist.

Application Details

Application Notes: Suitable for use in Western blot (0.5?1ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Concentration: Lot specific

Purification: Immunoaffinity chromatography

Buffer: PBS. Preservative: 0.02% Sodium azide

Storage: Store (up to one year) at 2-8°C. : This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Restrictions: For Research Use only

Publications

Publications: Cheng, Baltimore: "TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation." in: Genes & development, Vol. 10, Issue 8, pp. 963-73, 1996 (PubMed).

Rothe, Xiong, Shu et al.: "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8241-6, 1996 (PubMed).

Pomerantz, Baltimore: "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase." in: The EMBO journal, Vol. 18, Issue 23, pp. 6694-704, 2000 (PubMed).

Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).